About: Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study, the effects of natural bile acid, chenodeoxycholic acid (CDCA), on dietary obesity, UCP1 in both interscapular BAT and in white adipose tissue (brite cells in WAT), were characterized in dietary-obese mice. In the 8-week reversion, the CDCA intervention resulted in a dose-dependent reduction of obesity, dyslipidaemia and glucose intolerance, which could be largely explained by a transient decrease in food intake. The 3-week reversion revealed mild CDCA-dependent and food intake-independent induction of UCP1-mediated thermogenesis in interscapular BAT, negligible increase of UCP1 in subcutaneous WAT and a shift from carbohydrate to lipid oxidation In this study, the effects of natural bile acid, chenodeoxycholic acid (CDCA), on dietary obesity, UCP1 in both interscapular BAT and in white adipose tissue (brite cells in WAT), were characterized in dietary-obese mice. In the 8-week reversion, the CDCA intervention resulted in a dose-dependent reduction of obesity, dyslipidaemia and glucose intolerance, which could be largely explained by a transient decrease in food intake. The 3-week reversion revealed mild CDCA-dependent and food intake-independent induction of UCP1-mediated thermogenesis in interscapular BAT, negligible increase of UCP1 in subcutaneous WAT and a shift from carbohydrate to lipid oxidation (en)
Title	Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice (en)
skos:prefLabel	Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice (en)
skos:notation	RIV/67985823:_____/14:00431306!RIV15-GA0-67985823
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(7E12073), P(GA13-00871S)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kopecký, Jan Flachs, Pavel Bardová, Kristina Janovská, Petra Zouhar, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	14677
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/14:00431306
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	white adipose tissue; uncoupling protein 1; energy expenditure; bile acids (en)
http://linked.open.../riv/klicoveSlovo	uncoupling protein 1 energy expenditure white adipose tissue bile acids
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F04A0AFD445F]
http://linked.open...i/riv/nazevZdroje	International Journal of Obesity
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	DIABAT - Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes Enhancing energy expenditure in white adipose tissue by combination treatments using n-3 fatty acids, resveratrol and calorie restriction
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	38
http://linked.open...iv/tvurceVysledku	Kopecký, Jan Bardová, Kristina Flachs, Pavel Janovská, Petra Zouhar, Petr Duarte, F. V. Gomes, A. P. Palmeira, C. M. Rolo, A. P. Teodoro, J. S. Varela, A. T.
http://linked.open...ain/vavai/riv/wos	000340666900002
issn	0307-0565
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/ijo.2013.230

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