About: Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats

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About: Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We examined neurovascular coupling in rat sensorimotor cortex in response to transcallosal stimulation under nNOS inhibition by 7-NI. Although 7-NI did not significantly affect basal cerebral blood flow and cortical excitability, hemodynamic responses to the transcallosal stimulation were diminished implicating a role of nNOS in neurovascular coupling. Our findings demonstrate that NO contributes to the hemodynamic response to brain activation We examined neurovascular coupling in rat sensorimotor cortex in response to transcallosal stimulation under nNOS inhibition by 7-NI. Although 7-NI did not significantly affect basal cerebral blood flow and cortical excitability, hemodynamic responses to the transcallosal stimulation were diminished implicating a role of nNOS in neurovascular coupling. Our findings demonstrate that NO contributes to the hemodynamic response to brain activation (en)
Title	Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats (en)
skos:prefLabel	Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats (en)
skos:notation	RIV/67985823:_____/13:00422612!RIV14-GA0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP303/10/0999), P(GBP304/12/G069), P(GPP304/11/P386), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	Suppl.1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Brožíčková, Carole Otáhal, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	71362
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/13:00422612
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cerebral hemodynamic response; brain excitability; neuronal nitric oxide synthase; 7-nitroindazole; rat (en)
http://linked.open.../riv/klicoveSlovo	7-nitroindazole brain excitability cerebral hemodynamic response neuronal nitric oxide synthase rat
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7B16EFFE257F]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Vascular and nonvascular nature of ischemia-induced seizures in immature rats Project of excellence in the field of neuroscience The role of nitric oxide in experimentally induced seizures and epileptogenesis in rats.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Otáhal, Jakub Brožíčková, Carole
http://linked.open...ain/vavai/riv/wos	000328901900006
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	10 (xsd:int)

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