About: Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • This study presents novel insights into cutaneous cold transduction mechanisms by investigating the molecular mechanism of how camphor modulates cold transduction to induce sensitization to cooling. We used extracellular and patch clamp electrophysiological techniques in combination with transgenic mice, calcium imaging and a high throughput FLIPRTETRA-based screening assay and present first evidence of an involvement of KV7.2/3 channels, which form the neuronal M-current, in the modulation of TRPM8-dependent cold transduction in cutaneous cold nociceptors
  • This study presents novel insights into cutaneous cold transduction mechanisms by investigating the molecular mechanism of how camphor modulates cold transduction to induce sensitization to cooling. We used extracellular and patch clamp electrophysiological techniques in combination with transgenic mice, calcium imaging and a high throughput FLIPRTETRA-based screening assay and present first evidence of an involvement of KV7.2/3 channels, which form the neuronal M-current, in the modulation of TRPM8-dependent cold transduction in cutaneous cold nociceptors (en)
Title
  • Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition
  • Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition (en)
skos:prefLabel
  • Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition
  • Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition (en)
skos:notation
  • RIV/67985823:_____/13:00398866!RIV14-AV0-67985823
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 42
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 60257
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/13:00398866
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • nociceptor; channels of HEK293T; receptor TRPM8 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [96F2D2750513]
http://linked.open...i/riv/nazevZdroje
  • Journal of Neuroscience
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 33
http://linked.open...iv/tvurceVysledku
  • Touška, Filip
  • Vlachová, Viktorie
  • Lewis, R. J.
  • Reeh, P. W.
  • Sattler, S.
  • Vetter, I.
  • Zimmermann, K.
  • Alzheimer, Ch.
  • Belmonte, C.
  • Boukalová, Štěpána
  • Bressan, E.
  • Hager, U.
  • Hein, A.
  • Hessler, S.
  • Huth, T.
  • Leffler, A.
  • Nissen, M.
  • Parra, A.
http://linked.open...ain/vavai/riv/wos
  • 000325809800020
issn
  • 0270-6474
number of pages
http://bibframe.org/vocab/doi
  • 10.1523/JNEUROSCI.1473-13.2013
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 74 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software