About: Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor     Goto   Sponge   NotDistinct   Permalink

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Description
  • The binding of ATP to trimeric P2X receptors (P2XR) causes an enlargement of the receptor extracellular vestibule, leading to opening of the cation-selective transmembrane pore. We identified five residues in the extracellulat vestibule, V49, Y54, Q55, F324, and G325, as critical for P2X4R function
  • The binding of ATP to trimeric P2X receptors (P2XR) causes an enlargement of the receptor extracellular vestibule, leading to opening of the cation-selective transmembrane pore. We identified five residues in the extracellulat vestibule, V49, Y54, Q55, F324, and G325, as critical for P2X4R function (en)
Title
  • Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor
  • Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor (en)
skos:prefLabel
  • Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor
  • Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor (en)
skos:notation
  • RIV/67985823:_____/13:00392574!RIV14-GA0-67985823
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  • I, P(GBP304/12/G069), P(IAA500110910), Z(AV0Z50110509)
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  • 3
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  • 90148
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  • RIV/67985823:_____/13:00392574
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  • ATP; purinergic P2X receptor channels; transmembrane domain; extracellular vestibule; gating; ivermectin (en)
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  • US - Spojené státy americké
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  • [ADC4B84E4574]
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  • PLoS ONE
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  • 8
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  • Vávra, Vojtěch
  • Zemková, Hana
  • Tvrdoňová, Vendula
  • Kuzyk, Pavlo
  • Stojilkovic, S. S.
  • Rokic, Milos Boro
http://linked.open...ain/vavai/riv/wos
  • 000316546400037
http://linked.open...n/vavai/riv/zamer
issn
  • 1932-6203
number of pages
http://bibframe.org/vocab/doi
  • 10.1371/journal.pone.0059411
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