About: N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses

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About: N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Using a highly selective neuronal NO synthase (nNOS) inhibitor, Nw-propyl-L-arginine (L-NPA), we investigated the effects of nNOS in the development of seizures and neurobiological changes, during status epilepticus (SE) and the early latent period, using a kainic acid (KA)-induced seizure model in C57BL/6J mice. The results suggest that nNOS plays a contributory role in seizure severity during SE and is important for neurobiological changes, associated with the development of chronic epilepsy, in the early latent period of epileptogenesis and may represent a novel target for pharmacological modulation in the treatment of epilepsy Using a highly selective neuronal NO synthase (nNOS) inhibitor, Nw-propyl-L-arginine (L-NPA), we investigated the effects of nNOS in the development of seizures and neurobiological changes, during status epilepticus (SE) and the early latent period, using a kainic acid (KA)-induced seizure model in C57BL/6J mice. The results suggest that nNOS plays a contributory role in seizure severity during SE and is important for neurobiological changes, associated with the development of chronic epilepsy, in the early latent period of epileptogenesis and may represent a novel target for pharmacological modulation in the treatment of epilepsy (en)
Title	N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses (en)
skos:prefLabel	N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses (en)
skos:notation	RIV/67985823:_____/12:00385447!RIV13-GA0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP303/10/0999), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Otáhal, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	155183
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00385447
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aberrant sprouting; gliosis; nitric oxide; seizure; telemetry (en)
http://linked.open.../riv/klicoveSlovo	telemetry nitric oxide seizure aberrant sprouting gliosis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[777E78909E4F]
http://linked.open...i/riv/nazevZdroje	European Journal of Neuroscience
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of nitric oxide in experimentally induced seizures and epileptogenesis in rats.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	36
http://linked.open...iv/tvurceVysledku	Otáhal, Jakub Beamer, E. Sills, G. J. Thippeswamy, T.
http://linked.open...ain/vavai/riv/wos	000310683800006
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0953-816X
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/j.1460-9568.2012.08234.x
is http://linked.open...avai/riv/vysledek of	N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses

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