About: Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy

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About: Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The cytokine tumor necrosis factor a (TNFa) is an established pain modulator in both the peripheral and central nervous systems. Modulation of nociceptive synaptic transmission in the spinal cord dorsal horn (DH) is thought to be involved in the development and maintenance of several pathological pain states. Increased levels of TNFa and its receptors (TNFR) in dorsal root ganglion (DRG) cells and in the spinal cord DH have been shown to play an essential role in neuropathic pain processing. In the present experiments the effect of TNFa incubation on modulation of primary afferent synaptic activity was investigated in a model of peripheral neuropathy The cytokine tumor necrosis factor a (TNFa) is an established pain modulator in both the peripheral and central nervous systems. Modulation of nociceptive synaptic transmission in the spinal cord dorsal horn (DH) is thought to be involved in the development and maintenance of several pathological pain states. Increased levels of TNFa and its receptors (TNFR) in dorsal root ganglion (DRG) cells and in the spinal cord DH have been shown to play an essential role in neuropathic pain processing. In the present experiments the effect of TNFa incubation on modulation of primary afferent synaptic activity was investigated in a model of peripheral neuropathy (en)
Title	Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy (en)
skos:prefLabel	Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy (en)
skos:notation	RIV/67985823:_____/11:00372591!RIV12-AV0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/09/1228), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Špicarová, Diana Paleček, Jiří Nerandžič, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	213435
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/11:00372591
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TNF; neuropathy; pain (en)
http://linked.open.../riv/klicoveSlovo	pain TNF neuropathy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4AB4B08E3293]
http://linked.open...i/riv/nazevZdroje	Journal of Neuroinflammation
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular and molecular mechanisms of pain transmission at spinal cord level. Neuroscience Centre
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Nerandžič, Vladimír Paleček, Jiří Špicarová, Diana
http://linked.open...ain/vavai/riv/wos	000300341700001
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1742-2094
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1742-2094-8-177
is http://linked.open...avai/riv/vysledek of	Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy

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