About: Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats

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About: Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the study was to elucidate whether, when and where the transcripts of the clock genes Per1 and Per2 and the immediate early gene c-fos are spontaneously expressed and/or induced by light in the newborn retina. Endogenous expression of Per1 was detected in the neuroblastic retina, and Per2 expression was detected in the inner part of the neuroblastic retina from birth. Light pulses induced c-fos expression in ganglion cells from postnatal day 1 (P1). Light pulses also induced the expression of Per1 and c-fos in the retinal pigment epithelium until P3, but not afterward. Expression of Per2 was not photoresponsive until P10. The data demonstrate that the rat retina is photosensitive immediately after birth. During early postnatal development, the spatial distribution of spontaneous and light-induced gene expression within the retinal layers changes gradually The aim of the study was to elucidate whether, when and where the transcripts of the clock genes Per1 and Per2 and the immediate early gene c-fos are spontaneously expressed and/or induced by light in the newborn retina. Endogenous expression of Per1 was detected in the neuroblastic retina, and Per2 expression was detected in the inner part of the neuroblastic retina from birth. Light pulses induced c-fos expression in ganglion cells from postnatal day 1 (P1). Light pulses also induced the expression of Per1 and c-fos in the retinal pigment epithelium until P3, but not afterward. Expression of Per2 was not photoresponsive until P10. The data demonstrate that the rat retina is photosensitive immediately after birth. During early postnatal development, the spatial distribution of spontaneous and light-induced gene expression within the retinal layers changes gradually (en)
Title	Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats (en)
skos:prefLabel	Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats (en)
skos:notation	RIV/67985823:_____/10:00345610!RIV11-GA0-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/08/0503), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Matějů, Kristýna Sumová, Alena Bendová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	258513
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/10:00345610
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	development; retina; circadian clock (en)
http://linked.open.../riv/klicoveSlovo	retina development circadian clock
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[649F3A13373B]
http://linked.open...i/riv/nazevZdroje	Journal of Comparative Neurology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuroscience Centre Entrainment of the rat circadian system during ontogenesis
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	518
http://linked.open...iv/tvurceVysledku	Sumová, Alena Bendová, Zdeňka Matějů, Kristýna
http://linked.open...ain/vavai/riv/wos	280311700013
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0021-9967
number of pages	15 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats

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