About: Changes of parvalbumin expression in the spinal cord after peripheral inflammation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Parvalbumin (PV) is a calcium-binding protein that is expressed by numerous neuronal subpopulations in the central nervous system.There was a significant reduction of PV immunoreactivity in the superficial dorsal horn region ipsilateral to the arthritis after induction of the peripheral inflammation. The ipsilateral area and intensity of PV staining in this area were reduced to 38 % and 37 %, respectively, out of the total PV staining on both sides. It is suggested that this reduction may reflect decreased expression of PV in GABAergic inhibitory neurons. Reduction of PV concentration in the presynaptic GABAergic terminals could lead to potentiation of inhibitory transmission in the spinal cord. Our results suggest that changes in expression of calcium-binding proteins in spinal cord dorsal horn neurons may modulate nociceptive transmission Parvalbumin (PV) is a calcium-binding protein that is expressed by numerous neuronal subpopulations in the central nervous system.There was a significant reduction of PV immunoreactivity in the superficial dorsal horn region ipsilateral to the arthritis after induction of the peripheral inflammation. The ipsilateral area and intensity of PV staining in this area were reduced to 38 % and 37 %, respectively, out of the total PV staining on both sides. It is suggested that this reduction may reflect decreased expression of PV in GABAergic inhibitory neurons. Reduction of PV concentration in the presynaptic GABAergic terminals could lead to potentiation of inhibitory transmission in the spinal cord. Our results suggest that changes in expression of calcium-binding proteins in spinal cord dorsal horn neurons may modulate nociceptive transmission (en)
Title	Changes of parvalbumin expression in the spinal cord after peripheral inflammation Changes of parvalbumin expression in the spinal cord after peripheral inflammation (en)
skos:prefLabel	Changes of parvalbumin expression in the spinal cord after peripheral inflammation Changes of parvalbumin expression in the spinal cord after peripheral inflammation (en)
skos:notation	RIV/67985823:_____/09:00328959!RIV10-MSM-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/08/0256), P(GA305/06/1115), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Sojka, David Paleček, Jiří Zachařová, Gisela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	306703
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/09:00328959
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pain; parvalbumin; spinal cord; GABA (en)
http://linked.open.../riv/klicoveSlovo	GABA pain spinal cord parvalbumin
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2B21D98BFF3A]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Regulation of muscle phenotype under normal, experimental and pathological conditions Neuroscience Centre Cellular and molecular mechanisms of pain transmission at spinal cord level.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Paleček, Jiří Zachařová, Gisela Sojka, David
http://linked.open...ain/vavai/riv/wos	268125600015
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Changes of parvalbumin expression in the spinal cord after peripheral inflammation Changes of parvalbumin expression in the spinal cord after peripheral inflammation Changes of parvalbumin expression in the spinal cord after peripheral inflammation Changes of parvalbumin expression in the spinal cord after peripheral inflammation

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