About: Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Purinergic P2X receptors, activated by extracellular ATP, play a role in pain sensation and immune response. We studied the structure of the first transmembrane domains of the P2X4 receptor, and functional role of conserved tyrosine and other aromatic amino acids in five subtypes of P2X family. We found that aromatic residues contribute to regulation of agonist binding at P2X1, P2X2, P2X3, P2X4 and P2X7 receptors, and play an important role in channel gating Purinergic P2X receptors, activated by extracellular ATP, play a role in pain sensation and immune response. We studied the structure of the first transmembrane domains of the P2X4 receptor, and functional role of conserved tyrosine and other aromatic amino acids in five subtypes of P2X family. We found that aromatic residues contribute to regulation of agonist binding at P2X1, P2X2, P2X3, P2X4 and P2X7 receptors, and play an important role in channel gating (en)
Title	Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors (en)
skos:prefLabel	Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors (en)
skos:notation	RIV/67985823:_____/09:00328588!RIV10-MSM-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA500110702), P(IAA500110910), P(IAA5011408), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Obšil, Tomáš Zemková, Hana Vávra, Vojtěch Jindřichová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	315719
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/09:00328588
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purinergic receptors; gating; transmembrane domain (en)
http://linked.open.../riv/klicoveSlovo	transmembrane domain gating purinergic receptors
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CCEB59109D39]
http://linked.open...i/riv/nazevZdroje	Journal of Neurochemistry
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Structure and function of receptors activated by extracellular ATP Neuroscience Centre Purinergic P2X receptors and their role in suprachiasmatic nuclei of hypothalamus Desensitization and ATP binding site of purinergic P2X receptors
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	109
http://linked.open...iv/tvurceVysledku	Obšil, Tomáš Vávra, Vojtěch Zemková, Hana Jindřichová, Marie Stojilkovic, S. S.
http://linked.open...ain/vavai/riv/wos	265013700022
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0022-3042
number of pages	12 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors

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