About: The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. We investigate the systemic effect of a D1R agonist (A77636) and antagonist (SCH 23390) on hyperlocomotor activity and cognitive deficit induced by an NMDA receptor antagonist (MK-801). Administration of the D1R antagonist had no effect on cognitive function, but decreased hyperlocomotion induced by MK-801. Thus, based on our results, over-activation of D1Rs may exacerbate psychotic symptoms in patients with schizophrenia Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. We investigate the systemic effect of a D1R agonist (A77636) and antagonist (SCH 23390) on hyperlocomotor activity and cognitive deficit induced by an NMDA receptor antagonist (MK-801). Administration of the D1R antagonist had no effect on cognitive function, but decreased hyperlocomotion induced by MK-801. Thus, based on our results, over-activation of D1Rs may exacerbate psychotic symptoms in patients with schizophrenia (en)
Title	The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats (en)
skos:prefLabel	The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats (en)
skos:notation	RIV/67985823:_____/09:00328539!RIV10-MSM-67985823
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0517), P(GA309/07/0341), P(NR9178), Z(AV0Z50110509), Z(MZ0PCP2005)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Svoboda, Jan Valeš, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	311977
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/09:00328539
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	animal model; cognitive function; D1 receptor (en)
http://linked.open.../riv/klicoveSlovo	cognitive function animal model D1 receptor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5EC5FC482114]
http://linked.open...i/riv/nazevZdroje	International Journal of Neuropsychopharmacology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) Influence of metabotropic glutamate receptor agonists on cognitive deficit in animal model of schizophrenia like behavioral. Behavioral pharmacology of spatial cognition and its application in research of an snímal model of schizophrenia
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Bubeníková-Valešová, V. Horáček, J. Svoboda, Jan Valeš, Karel
http://linked.open...ain/vavai/riv/wos	268624700002
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Study of Sources f Psychiatric Morbidity , and Increasing the Effec-tiveness of the Preventative and Therapeutical methods in mental Health Care in the Czech Republic 2005?2011
issn	1461-1457
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 11 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software