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Description
| - Intrahippocampal injection of Endothelin-1 (ET-1) in doses 10-40 pmol induced epileptic seizures in 80-100% of both P12 and P25 animals. Within 100 min after injection, both convulsive and non-convulsive were detected with video/EEG monitoring of freely moving animals. After 24h epileptiform activity was still present in majority of animals, but seizures were non-convulsive. Morphological examination confirmed neurodegeneration in the injected hippocampus, which was more extensive in P12 than in P25 rats
- Intrahippocampal injection of Endothelin-1 (ET-1) in doses 10-40 pmol induced epileptic seizures in 80-100% of both P12 and P25 animals. Within 100 min after injection, both convulsive and non-convulsive were detected with video/EEG monitoring of freely moving animals. After 24h epileptiform activity was still present in majority of animals, but seizures were non-convulsive. Morphological examination confirmed neurodegeneration in the injected hippocampus, which was more extensive in P12 than in P25 rats (en)
- Intrahipokampální injekce endothelinu-1 (ET-1) vyvolává epileptické záchvaty u 80-100% P12 i P25 potkanů. V průběhu 100 min po aplikaci byla zjištěna přítomnost konvusivních i nekonvulsivních záchvatů, po 24 h byla nalezena epileptiformní aktivita bez křečí u většiny zvířat. Morfologická analýza prokázala ztrátu neuronů v ipsilaterálním hipokampu. Rozsah poškození byl větší u P12 než u P25 zvířat (cs)
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Title
| - Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats
- Intrahipokampální injekce endothelinu-1, nový model epileptických záchvatů vyvolaných ischemií u mláďat potkanů (cs)
- Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats (en)
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skos:prefLabel
| - Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats
- Intrahipokampální injekce endothelinu-1, nový model epileptických záchvatů vyvolaných ischemií u mláďat potkanů (cs)
- Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats (en)
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skos:notation
| - RIV/67985823:_____/07:00096380!RIV08-AV0-67985823
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA305/06/0713), P(GD305/03/H148), P(LC554), Z(AV0Z50110509)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/07:00096380
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - endothelin-1; epileptic seizures; immature rats (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Mareš, Pavel
- Kubová, Hana
- Otáhal, Jakub
- Tsenov, Grygoriy
- Mátéffyová, Adéla
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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