About: Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats     Goto   Sponge   NotDistinct   Permalink

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Description
  • Intrahippocampal injection of Endothelin-1 (ET-1) in doses 10-40 pmol induced epileptic seizures in 80-100% of both P12 and P25 animals. Within 100 min after injection, both convulsive and non-convulsive were detected with video/EEG monitoring of freely moving animals. After 24h epileptiform activity was still present in majority of animals, but seizures were non-convulsive. Morphological examination confirmed neurodegeneration in the injected hippocampus, which was more extensive in P12 than in P25 rats
  • Intrahippocampal injection of Endothelin-1 (ET-1) in doses 10-40 pmol induced epileptic seizures in 80-100% of both P12 and P25 animals. Within 100 min after injection, both convulsive and non-convulsive were detected with video/EEG monitoring of freely moving animals. After 24h epileptiform activity was still present in majority of animals, but seizures were non-convulsive. Morphological examination confirmed neurodegeneration in the injected hippocampus, which was more extensive in P12 than in P25 rats (en)
  • Intrahipokampální injekce endothelinu-1 (ET-1) vyvolává epileptické záchvaty u 80-100% P12 i P25 potkanů. V průběhu 100 min po aplikaci byla zjištěna přítomnost konvusivních i nekonvulsivních záchvatů, po 24 h byla nalezena epileptiformní aktivita bez křečí u většiny zvířat. Morfologická analýza prokázala ztrátu neuronů v ipsilaterálním hipokampu. Rozsah poškození byl větší u P12 než u P25 zvířat (cs)
Title
  • Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats
  • Intrahipokampální injekce endothelinu-1, nový model epileptických záchvatů vyvolaných ischemií u mláďat potkanů (cs)
  • Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats (en)
skos:prefLabel
  • Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats
  • Intrahipokampální injekce endothelinu-1, nový model epileptických záchvatů vyvolaných ischemií u mláďat potkanů (cs)
  • Intrahippocampal Injection of Endothelin-1: A New Model of Ischemia-induced Seizures in Immature Rats (en)
skos:notation
  • RIV/67985823:_____/07:00096380!RIV08-AV0-67985823
http://linked.open.../vavai/riv/strany
  • 7;13
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/06/0713), P(GD305/03/H148), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika
  • Suppl.5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 427334
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/07:00096380
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • endothelin-1; epileptic seizures; immature rats (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [94ACF0DC91C5]
http://linked.open...i/riv/nazevZdroje
  • Epilepsia
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 48
http://linked.open...iv/tvurceVysledku
  • Mareš, Pavel
  • Kubová, Hana
  • Otáhal, Jakub
  • Tsenov, Grygoriy
  • Mátéffyová, Adéla
http://linked.open...n/vavai/riv/zamer
issn
  • 0013-9580
number of pages
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