| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - The surface of poly(L-lactide) (PLLA) films deposited on glass coverslips was modified with poly(DL-lactide) (PDLLA), or 1 : 4 mixtures of PDLLA and PDLLA-b-PEO block copolymers, in which either none, 5% or 20% of the copolymer molecules carried a synthetic extracellular matrix-derived ligand for integrin adhesion receptors, the GRGDSG oligopeptide, attached to the end of the PEO chain. The PDLLA-b-PEO copolymer alone did not support the adhesion and growth of vascular smooth muscle cells in cultures derived from the rat aorta. However, when functionalized with the GRGDSG, it allowed cell spreading, formation of vinculin-containing focal adhesion plaques, DNA synthesis and even cell proliferation in a serum-free medium, which indicates specific binding of cells to the GRGDSG sequences through their adhesion receptors
- The surface of poly(L-lactide) (PLLA) films deposited on glass coverslips was modified with poly(DL-lactide) (PDLLA), or 1 : 4 mixtures of PDLLA and PDLLA-b-PEO block copolymers, in which either none, 5% or 20% of the copolymer molecules carried a synthetic extracellular matrix-derived ligand for integrin adhesion receptors, the GRGDSG oligopeptide, attached to the end of the PEO chain. The PDLLA-b-PEO copolymer alone did not support the adhesion and growth of vascular smooth muscle cells in cultures derived from the rat aorta. However, when functionalized with the GRGDSG, it allowed cell spreading, formation of vinculin-containing focal adhesion plaques, DNA synthesis and even cell proliferation in a serum-free medium, which indicates specific binding of cells to the GRGDSG sequences through their adhesion receptors (en)
- Povrch poly(L-laktidových ) (PLLA) filmů, nanesených na mikroskopická krycí skla, byl modifikován poly(DL-laktidem) (PDLLA) nebo směsí PDLLA a blokových kopolymerů PDLLA-b-PEO, ve kterých 0%, 5% nebo 20% molekul kopolymeru neslo syntetický ligand pro integrinové adhesní receptory , a sice oligopeptid GRGDSG, navázaný na konec řetězce PEO. Kopolymer PDLLA-b-PEO nepodporoval adhesi a růst cévních hladkých svalových buněk v kulturách založených z aorty potkana. Po funkcionalizaci GRGDSG však materiál umožňoval rozprostření buněk, tvorbu fokálních adhesních plaků obsahujících vinkulin, syntesu DNA a dokonce proliferaci buněk v bezsérovém médiu, což svědčí pro specifickou vazbu buněk k sekvencím GRGDSG pomocí adhesních receptorů (cs)
|
| Title
| - Adhesion and growth of vascular smooth muscle cells in cultures on bioactive RGD peptide-carrying polylactides
- Adhesion and growth of vascular smooth muscle cells in cultures on bioactive RGD peptide-carrying polylactides (en)
- Adhese a růst cévních hladkých svalových buněk v kulturách na bioaktivních polylaktidech s peptidy obsahujícími sekvenci RGD (cs)
|
| skos:prefLabel
| - Adhesion and growth of vascular smooth muscle cells in cultures on bioactive RGD peptide-carrying polylactides
- Adhesion and growth of vascular smooth muscle cells in cultures on bioactive RGD peptide-carrying polylactides (en)
- Adhese a růst cévních hladkých svalových buněk v kulturách na bioaktivních polylaktidech s peptidy obsahujícími sekvenci RGD (cs)
|
| skos:notation
| - RIV/67985823:_____/07:00092835!RIV08-AV0-67985823
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1QS500110564), P(IAA4050202), Z(AV0Z40500505), Z(AV0Z50110509)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/07:00092835
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - tissue engineering; integrin-mediated cell adhesion; bioartificial tissue (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Journal of Materials Science-Materials in Medicine
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Bačáková, Lucie
- Filová, Elena
- Kubies, Dana
- Rypáček, František
- Proks, Vladimír
- Machová, Luďka
- Malinova, V.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| is http://linked.open...avai/riv/vysledek
of | |
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