About: Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547

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About: Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nová anticholinesteráza C-547 zvyšuje amplitudu a prodlužuje trvání MEPCs, což je typické pro anticholiesterázové působení. U soleu a EDL jsme zjistili výraznou potenciaci v nanomolárních koncentracích, zatím co u bránice se amplituda a konstanta poklesu tau zvyšují až při dávce 100 nM. Jsou diskutovány možné důsledky tohoto rozdílu (cs) A novel derivative of 6-methyluracil, C-547, increased the amplitude and prolonged the duration of miniature enplate currents (MEPCs) with is typical for acetylcholinesterase inhibition. In the soleus and extensor digitorum longus significant potentiation was detected at nanomolar concentrations. In contrast, in the diaphragm muscle, the increase in the amplitudes of the MEPCs and the decay time constant tau appeared only when the concetration of C-547 was elevated to 1x10 M. Possible consequences for the exploitation of this drug, which can selectively inhibit AChE in particular synapses, are discussed A novel derivative of 6-methyluracil, C-547, increased the amplitude and prolonged the duration of miniature enplate currents (MEPCs) with is typical for acetylcholinesterase inhibition. In the soleus and extensor digitorum longus significant potentiation was detected at nanomolar concentrations. In contrast, in the diaphragm muscle, the increase in the amplitudes of the MEPCs and the decay time constant tau appeared only when the concetration of C-547 was elevated to 1x10 M. Possible consequences for the exploitation of this drug, which can selectively inhibit AChE in particular synapses, are discussed (en)
Title	Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547 Různá citlivost miniaturních proudů nervosvalové ploténky u potkanů na svalech extensor dogitorum longus, soleus k nové anticholinesterázové inhibiční látce C-547 (cs) Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547 (en)
skos:prefLabel	Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547 Různá citlivost miniaturních proudů nervosvalové ploténky u potkanů na svalech extensor dogitorum longus, soleus k nové anticholinesterázové inhibiční látce C-547 (cs) Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547 (en)
skos:notation	RIV/67985823:_____/06:00045261!RIV07-AV0-67985823
http://linked.open.../vavai/riv/strany	585;589
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/1333), P(IAA5011411), P(LC554), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Vyskočil, František
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	471640
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/06:00045261
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholine; anticholinesterase (en)
http://linked.open.../riv/klicoveSlovo	anticholinesterase acetylcholine
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[66AD3A87E1D3]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuroscience Centre Transmitter Release and Action at Neuromuscular Synapse New Principles of Motor synypse regulation
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Vyskočil, František Nikolsky, E. E. Bukharaeva, E. A. Kovyazina, I. V. Petrov, K. A. Zobov, V. V.
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	0862-8408
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547 Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547

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