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rdf:type
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Description
| - Ivermektin aplikovaný extracelulárně zvyšuje citlivost P2X4 receptoru k ATP, zvyšuje maximální proudovou odpověď a výrazně prodlužuje kinetiku deaktivace kanálu. V tomto článku jsem ukázali, že aminokyselinové zbytky Trp50, Val60 a Val357 hrají důležitou roli v ivermectinové regulaci rychlosti deaktivace, ale ne v regulaci maximální amplitudy odpovědi (cs)
- Ivermectin applied extracellularly increases the sensitivity of P2X4 receptor to ATP, enhances the maximum current amplitudes, and greatly prolongs the deactivation kinetics. In this manuscript, we showed the importance of Trp50, Val60, and Val357 residues in ivermectin regulation of the rate of channel deactivation, but not on the maximum current amplitude
- Ivermectin applied extracellularly increases the sensitivity of P2X4 receptor to ATP, enhances the maximum current amplitudes, and greatly prolongs the deactivation kinetics. In this manuscript, we showed the importance of Trp50, Val60, and Val357 residues in ivermectin regulation of the rate of channel deactivation, but not on the maximum current amplitude (en)
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Title
| - Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation
- Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation (en)
- Identifikace P2X4 receptor-specifických zbytků podílejících se na účinku ivermektinu na deaktivaci iontového kanálu (cs)
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skos:prefLabel
| - Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation
- Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation (en)
- Identifikace P2X4 receptor-specifických zbytků podílejících se na účinku ivermektinu na deaktivaci iontového kanálu (cs)
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skos:notation
| - RIV/67985823:_____/06:00042263!RIV07-AV0-67985823
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(IAA5011408), P(LC554), Z(AV0Z50110509)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/67985823:_____/06:00042263
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - purinergic receptor-channels; ATP; ivermectin (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Biochemical and Biophysical Research Communications
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Teisinger, Jan
- Zemková, Hana
- Stojilkovic, S. S.
- Yan, Z.
- Jelínková, Irena
- Liang, Z.
- Moonat, S.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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