About: Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V review jsou shrnuty nejnovější znalosti o mitochondriích jako zdroji reaktivních kyslíkových sloučenin, o výtoku superoxidu, peroxidu vodíku z mitochondrií, o tvorbě peroxinitritu a mitochondriálního NO a jejich efektech. Vyslovili jsme hypotézu, že náhlý pokles generace superoxidu v mitochondriích způsobí, že detoxifikační mechanismy mají volnou kapacitu na snížení reaktivních kyslíkových sloučenin a oxidačních modifikací jak v cytosolu tak v extracellulárním milieu (cs) The recent knowledge on mitochondria as the substantial source of reactive oxygen species, namely superoxide and hydrogen peroxide efflux from mitochondria, is reviewed, as well as nitric oxide and subsequent peroxynitrite generation in mitochondria and their effects. We hypothesize that a sudden decline of mitochondrial ROS production converts cells or their microenvironment into a “ROS sink” represented by the instantly released excessive capacity of ROS-detoxification mechanisms The recent knowledge on mitochondria as the substantial source of reactive oxygen species, namely superoxide and hydrogen peroxide efflux from mitochondria, is reviewed, as well as nitric oxide and subsequent peroxynitrite generation in mitochondria and their effects. We hypothesize that a sudden decline of mitochondrial ROS production converts cells or their microenvironment into a “ROS sink” represented by the instantly released excessive capacity of ROS-detoxification mechanisms (en)
Title	Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism Mitochondrie v homeostáze reaktivních kyslíkových sloučenin v buňce, tkáních a organismu (cs) Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism (en)
skos:prefLabel	Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism Mitochondrie v homeostáze reaktivních kyslíkových sloučenin v buňce, tkáních a organismu (cs) Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism (en)
skos:notation	RIV/67985823:_____/05:00025110!RIV06-AV0-67985823
http://linked.open.../vavai/riv/strany	2478;2503
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/04/0495), P(GA301/02/1215), P(GA301/05/0221), P(IAA5011106), Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Ježek, Petr Plecitá-Hlavatá, Lydie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	530399
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/05:00025110
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mitochondria; reactive oxygen species; oxidative stress (en)
http://linked.open.../riv/klicoveSlovo	mitochondria oxidative stress reactive oxygen species
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D4A703B0B12E]
http://linked.open...i/riv/nazevZdroje	International Journal of Biochemistry and Cell Biology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Characterization of mRNA variations for novel mitochondrial uncoupling proteins during stimulations by pyrogenic cytokines, thyroid hormones and lipoid compound Elucidation of role of mitochondrial factor CIDEa in normal physiology, antioxidant defense, and in type-2 diabetes and obesity Interaction of superoxide and reactive oxigen species with mitochondral uncoupling proteins Studies of novel mitochondrial uncoupling proteins
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	37
http://linked.open...iv/tvurceVysledku	Ježek, Petr Hlavatá, Lydie
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1357-2725
number of pages	26 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism

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