About: Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis

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About: Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.jneuroim.2012.10.014
Description	We investigated the HLA-DRB11501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.. We investigated the HLA-DRB11501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.. (en)
Title	Association of HLA-DRB11501 tagging rs3135388 gene polymorphism with multiple sclerosis Association of HLA-DRB11501 tagging rs3135388 gene polymorphism with multiple sclerosis (en)
skos:prefLabel	Association of HLA-DRB11501 tagging rs3135388 gene polymorphism with multiple sclerosis Association of HLA-DRB11501 tagging rs3135388 gene polymorphism with multiple sclerosis (en)
skos:notation	RIV/65269705:_____/13:#0002135!RIV14-MZ0-65269705
http://linked.open...avai/predkladatel	Fakultní nemocnice Brno
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Benešová, Yvone Hladíková, Magdalena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	62353
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/13:#0002135
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Gene; HLA-DRB1*1501; Multiple sclerosis; Tagging polymorphism (en)
http://linked.open.../riv/klicoveSlovo	HLA-DRB1*1501 Tagging polymorphism Gene Multiple sclerosis
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[20A39589A7E0]
http://linked.open...i/riv/nazevZdroje	Journal of neuroimmunology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	255
http://linked.open...iv/tvurceVysledku	Hladíková, Magdalena Benešová, Yvonne
http://linked.open...ain/vavai/riv/wos	000315014700013
issn	0165-5728
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jneuroim.2012.10.014

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