About: Mechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemia

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About: Mechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.3324/haematol.2013.086355
Description	For the first time we have clarified the mechanism of impaired glucose metabolism in CML patients treated with nilotinib, which occurs via rapidly developed tissue insulin resistance and compensatory hyperinsulinemia. It also at least partially explains the fast development of dyslipidemia and probably also PAO in these CML patients. However, further studies that include a larger patient cohort, as well as in vitro tests to confirm postreceptor insulin resistance, are needed, and these are already ongoing in our study group.. For the first time we have clarified the mechanism of impaired glucose metabolism in CML patients treated with nilotinib, which occurs via rapidly developed tissue insulin resistance and compensatory hyperinsulinemia. It also at least partially explains the fast development of dyslipidemia and probably also PAO in these CML patients. However, further studies that include a larger patient cohort, as well as in vitro tests to confirm postreceptor insulin resistance, are needed, and these are already ongoing in our study group.. (en)
Title	Mechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemia Mechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemia (en)
skos:prefLabel	Mechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemia Mechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemia (en)
skos:notation	RIV/65269705:_____/13:#0002130!RIV14-MZ0-65269705
http://linked.open...avai/predkladatel	Fakultní nemocnice Brno
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Semerád, Lukáš Žáčková, Daniela Ráčil, Z. Mayer, Jiří Malášková, Ludmila Rázga, Filip Palacková, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	87019
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/13:#0002130
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Nilotinib; insulin resistance (en)
http://linked.open.../riv/klicoveSlovo	Nilotinib insulin resistance
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[55DE6D8DC25A]
http://linked.open...i/riv/nazevZdroje	Haematologica
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	98
http://linked.open...iv/tvurceVysledku	Mayer, Jiří Rázga, Filip Ráčil, Zdeněk Žáčková, Daniela Palacková, Martina Malášková, Ludmila Semerád, Lukáš
http://linked.open...ain/vavai/riv/wos	000328543400001
issn	0390-6078
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.3324/haematol.2013.086355

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