About: Per3 VNTR polymorphism and chronic heart failure

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aims: The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF). Methods: The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR. Results: No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (Pg=0.30, Pa=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; Pg=0.87, Pa=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found. Conclusion: Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population. Aims: The aim of this study was to investigate the relationship between gene Period3 (Per3) variable number tandem repeat (VNTR) polymorphism and chronic heart failure (CHF). Methods: The study subjects (372 patients of Caucasian origin with CHF and 332 healthy controls) were genotyped for Per3 VNTR polymorphism using an allele-specific PCR. Results: No significant differences in genotype or Per3 VNTR allele frequencies were found between CHF cases and controls (Pg=0.30, Pa=0.52). No significant differences were uncovered either between CHF cases according to etiology (DCMP vs. IHD; Pg=0.87, Pa=0.91). In the multivariate regression modeling, no predictive function of VNTR Per3 polymorphism on ejection fraction or NYHA class, hyperlipidaemia or type II diabetes risk was found. Conclusion: Per3 VNTR polymorphism is not a major risk factor for chronic heart failure or a factor modulating the severity of the CHF in this population. (en)
Title	Per3 VNTR polymorphism and chronic heart failure Per3 VNTR polymorphism and chronic heart failure (en)
skos:prefLabel	Per3 VNTR polymorphism and chronic heart failure Per3 VNTR polymorphism and chronic heart failure (en)
skos:notation	RIV/65269705:_____/12:#0001853!RIV13-MZ0-65269705
http://linked.open...avai/predkladatel	Fakultní nemocnice Brno
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NS10206)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pařenica, Jiří Špinar, Jindřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	158373
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/12:#0001853
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	circadian clock (en)
http://linked.open.../riv/klicoveSlovo	circadian clock
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3EBF42335981]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers of the Medical Faculty of Palacky University in Olomouc
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Association of polymorphisms in genes for matrix metalloproteinases, their inhibitors, ACE and ACE2 with central pulse pressure in cardiovascular patients
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	156
http://linked.open...iv/tvurceVysledku	Pařenica, Jiří Špinar, Jindřich Pávková Goldbergrová, Monika
issn	1213-8118
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.5507/bp.2012.069
is http://linked.open...avai/riv/vysledek of	Per3 VNTR polymorphism and chronic heart failure

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