About: Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications

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About: Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or background microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenic property of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic cells with respect to the presence of these molecule deserve further studies. Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or background microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenic property of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic cells with respect to the presence of these molecule deserve further studies. (en)
Title	Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications (en)
skos:prefLabel	Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications (en)
skos:notation	RIV/65269705:_____/12:#0001845!RIV13-MZ0-65269705
http://linked.open...avai/predkladatel	Fakultní nemocnice Brno
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(NS9871)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Štěrba, Jaroslav Král, Zdeněk Janíková, Andrea Křen, L. Souček, Ondřej Křenová, Zdeňka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	152348
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/12:#0001845
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hodgkin lymphoma (en)
http://linked.open.../riv/klicoveSlovo	hodgkin lymphoma
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[C0858342FC91]
http://linked.open...i/riv/nazevZdroje	Pathology, research and practice
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Optimized dendritic cells loaded with universal tumor antigens as a potent individualized cancer vaccine Central european institute of technology
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	208
http://linked.open...iv/tvurceVysledku	Souček, Ondřej Štěrba, Jaroslav Janíková, Andrea Král, Zdeněk Křen, Leoš Křenová, Zdeňka
http://linked.open...ain/vavai/riv/wos	000300602900007
issn	0344-0338
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.prp.2011.11.004
is http://linked.open...avai/riv/vysledek of	Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications

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