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  • In an effort to influence the poor prognosis and yet unsatisfactory results of treatment in patients with advanced locoregional and metastatic non-small cell lung cancer are being developed and clinically tested other medications, which include a new small molecule oral administration afatinib (BIBW 2992) with a dual effect consisting in irreversible blockade EGFR and HER2. So far, results have been announced preclinical studies and study II. and II. / III. phase, further testing is conducted. Results and conclusions are presented in this article.
  • In an effort to influence the poor prognosis and yet unsatisfactory results of treatment in patients with advanced locoregional and metastatic non-small cell lung cancer are being developed and clinically tested other medications, which include a new small molecule oral administration afatinib (BIBW 2992) with a dual effect consisting in irreversible blockade EGFR and HER2. So far, results have been announced preclinical studies and study II. and II. / III. phase, further testing is conducted. Results and conclusions are presented in this article. (cs)
  • Ve snaze ovlivnit špatnou prognózu a dosud neuspokojivé výsledky léčby u nemocných s metastazujícím a lokoregionálně pokročilým nemalobuněčným karcinomem plic jsou vyvíjeny a klinicky testovány další léky, k nimž patří i nová malá molekula k perorálnímu podávání afatinib (BIBW 2992) s duálním účinkem spočívajícím v ireverzibilní blokádě EGFR i HER2. Dosud jsou známy výsledky preklinických studií a studie II. a II./III. fáze, další testování probíhá. Dosavadní výsledky a závěry jsou uvedeny v tomto článku. (en)
Title
  • Afatinib - a new perspective in non-small cell lung cancer (en)
  • Afatinib - nová perspektiva u nemalobuněčného karcinomu plic
  • Afatinib - nová perspektiva u nemalobuněčného karcinomu plic (cs)
skos:prefLabel
  • Afatinib - a new perspective in non-small cell lung cancer (en)
  • Afatinib - nová perspektiva u nemalobuněčného karcinomu plic
  • Afatinib - nová perspektiva u nemalobuněčného karcinomu plic (cs)
skos:notation
  • RIV/65269705:_____/11:#0001375!RIV12-MZ0-65269705
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 184807
http://linked.open...ai/riv/idVysledku
  • RIV/65269705:_____/11:#0001375
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • afatinib (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [F606AAAC9B01]
http://linked.open...i/riv/nazevZdroje
  • Farmakoterapie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 7
http://linked.open...iv/tvurceVysledku
  • Babičková, Lenka
issn
  • 1801-1209
number of pages
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