About: Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Despite novel treatment strategies, multiple myeloma (MM) remains an incurable disease with low immunogenicity and multiple immune defects. We developed an ex vivo strategy for inducing myeloma-specific cytotoxic T lymphocytes (CTLs) and demonstrate the possibility of identification and long-term in vivo monitoring of individual myeloma-specific T-cell clones using the most sensitive clonotypic assay that is able to detect low frequencies of T-cell clones (1 clonotypic cell in 10(6) cells). Ten patients with MM were examined for the presence of tumour-reactive T cells using dendritic cells loaded with autologous tumour cells. All patients had detectable myeloma-reactive T cells in vitro. Expanded myeloma-reactive T cells demonstrated specific cytotoxic effects against autologous tumour cells in vitro (median 39.6% at an effector:target ratio of 40:1). Despite novel treatment strategies, multiple myeloma (MM) remains an incurable disease with low immunogenicity and multiple immune defects. We developed an ex vivo strategy for inducing myeloma-specific cytotoxic T lymphocytes (CTLs) and demonstrate the possibility of identification and long-term in vivo monitoring of individual myeloma-specific T-cell clones using the most sensitive clonotypic assay that is able to detect low frequencies of T-cell clones (1 clonotypic cell in 10(6) cells). Ten patients with MM were examined for the presence of tumour-reactive T cells using dendritic cells loaded with autologous tumour cells. All patients had detectable myeloma-reactive T cells in vitro. Expanded myeloma-reactive T cells demonstrated specific cytotoxic effects against autologous tumour cells in vitro (median 39.6% at an effector:target ratio of 40:1). (en)
Title	Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma (en)
skos:prefLabel	Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma (en)
skos:notation	RIV/65269705:_____/10:#0001047!RIV11-MZ0-65269705
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1A8709), P(2B06058), P(LC06027), P(NR8945)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pour, Luděk Slabý, Ondřej Dudová, Silvie Hájek, Roman Michálek, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	263445
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/10:#0001047
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple myeloma (en)
http://linked.open.../riv/klicoveSlovo	multiple myeloma
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2C778D5237CD]
http://linked.open...i/riv/nazevZdroje	British Journal of Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	In vitro separation and molecular analysis of graft-versus-host-specific and graft-versus-tumor-specific T cells Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma University Research Centre - Czech Myeloma Group Safer biotechnology of the allogeneic hematopoietic stem cells in solid and hematological cancer as an adoptive immunotherapy
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	148
http://linked.open...iv/tvurceVysledku	Hájek, Roman Michálek, Jaroslav Pour, Luděk Slabý, Ondřej Dudová, Silvie
http://linked.open...ain/vavai/riv/wos	000275094900005
issn	0007-1048
number of pages	9 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma Individual myeloma - specific T-cell clones eliminate tumor cells and correlate with clinical outcomes in patients with multiple myeloma

Faceted Search & Find service v1.16.116 as of Feb 22 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3239 as of Feb 22 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software