About: Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	42 patients were recruited prospectively and underwent a clinical examination,nerve conduction studies, quantitative sensory testing(QST)and skin biopsy at the dorsum of the foot.All patients had a correlate for their dysesthesias in at least one diagnostic modality.Most patients(>90%)had signs of small fiber loss or dysfunction.In about half of all patients large fibers were also affected.Nerve conduction studies were abnormal in 23/42 patients(54.8%).Cold or warm detection thresholds in QST were abnormal in 15/42(35.7%)patients.Decreased intraepidermal nerve fiber density(IENFD)was found in 37 patients(88.1%)including some patients with normal QST findings.Nearly all patients with pathological QST had a reduced IENFD,indicating a high positive predictive value(93%)of QST in screening for reduced IENFD as correlate for neuropathy.Therefore in all patients with lower limb dysesthesias of unknown origin,the non-invasive methods of NCS and QST should be used and potentially complemented by skin biopsy 42 patients were recruited prospectively and underwent a clinical examination,nerve conduction studies, quantitative sensory testing(QST)and skin biopsy at the dorsum of the foot.All patients had a correlate for their dysesthesias in at least one diagnostic modality.Most patients(>90%)had signs of small fiber loss or dysfunction.In about half of all patients large fibers were also affected.Nerve conduction studies were abnormal in 23/42 patients(54.8%).Cold or warm detection thresholds in QST were abnormal in 15/42(35.7%)patients.Decreased intraepidermal nerve fiber density(IENFD)was found in 37 patients(88.1%)including some patients with normal QST findings.Nearly all patients with pathological QST had a reduced IENFD,indicating a high positive predictive value(93%)of QST in screening for reduced IENFD as correlate for neuropathy.Therefore in all patients with lower limb dysesthesias of unknown origin,the non-invasive methods of NCS and QST should be used and potentially complemented by skin biopsy (en)
Title	Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities (en)
skos:prefLabel	Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities (en)
skos:notation	RIV/65269705:_____/09:#0000803!RIV10-MZ0-65269705
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Moravcová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	332528
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/09:#0000803
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dysesthesias; neuropathy; skin biopsy (en)
http://linked.open.../riv/klicoveSlovo	dysesthesias neuropathy skin biopsy
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DEDA6D22F626]
http://linked.open...i/riv/nazevZdroje	European Journal of Pain
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Vlčková-Moravcová, Eva Scherens, A.
http://linked.open...ain/vavai/riv/wos	000268384500006
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	1090-3801
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities

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