About: The promotor polymorphism of macrophage metalloelastase in multiple sclerosis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Multiple sclerosis is a chronic demyelinating disease of the central nervous system in which the genetic background plays an important role. Its pathophysiology is characterised by two major processes: neuroinflammation and neurodegeneration. Matrix metalloproteinases are involved in both of them. Macrophage metalloelastase is one of the three matrix metalloproteinases the common elevation of which has been confirmed in multiple sclerosis and also in animal models with experimental allergic encephalomyelitis. To assess the association between its promotor polymorphism and demyelinating disease we genotyped a total of 92 patients (23 men, 69 women, mean age 37 years) with definite multiple sclerosis (according to the McDonald criteria) and 51 healthy controls (17 men, 34 women) matched for age and sex Multiple sclerosis is a chronic demyelinating disease of the central nervous system in which the genetic background plays an important role. Its pathophysiology is characterised by two major processes: neuroinflammation and neurodegeneration. Matrix metalloproteinases are involved in both of them. Macrophage metalloelastase is one of the three matrix metalloproteinases the common elevation of which has been confirmed in multiple sclerosis and also in animal models with experimental allergic encephalomyelitis. To assess the association between its promotor polymorphism and demyelinating disease we genotyped a total of 92 patients (23 men, 69 women, mean age 37 years) with definite multiple sclerosis (according to the McDonald criteria) and 51 healthy controls (17 men, 34 women) matched for age and sex (en)
Title	The promotor polymorphism of macrophage metalloelastase in multiple sclerosis The promotor polymorphism of macrophage metalloelastase in multiple sclerosis (en)
skos:prefLabel	The promotor polymorphism of macrophage metalloelastase in multiple sclerosis The promotor polymorphism of macrophage metalloelastase in multiple sclerosis (en)
skos:notation	RIV/65269705:_____/09:#0000764!RIV10-MZ0-65269705
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Štourač, Pavel Benešová, Yvone Hladíková, Magdalena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	337133
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/09:#0000764
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	matrix metalloproteinases; macrophage metalloelastase; multiple sclerosis (en)
http://linked.open.../riv/klicoveSlovo	multiple sclerosis matrix metalloproteinases macrophage metalloelastase
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[0BEC842A16DB]
http://linked.open...i/riv/nazevZdroje	Sripta medica
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	82
http://linked.open...iv/tvurceVysledku	Štourač, Pavel Benešová, Yvone Hladíková, Magdalena
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	1211-3395
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The promotor polymorphism of macrophage metalloelastase in multiple sclerosis The promotor polymorphism of macrophage metalloelastase in multiple sclerosis The promotor polymorphism of macrophage metalloelastase in multiple sclerosis The promotor polymorphism of macrophage metalloelastase in multiple sclerosis

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