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| Description
| - We investigated the association of matrix metalloproteinase-9 (-1562C/T, +279R/Q) and matrix metalloproteinase-2 (-1575G/A, -1306C/T) gene polymorphisms with multiple sclerosis (MS) susceptibility, gender differences and disability in 244 patients and 132 healthy subjects. A significant decrease of the -1562T allele carriers in MS patients compared to controls (Pa=0.01, Pacorr=0.05) in -1562C/T MMP-9 gene polymorphism was found, (odds ratio (OR) -0.58, 95% confidence interval (CI):0.38-0.89). Significant differences were also demonstrated between female patients and healthy females (Pa=0.01, Pacorr=0.05), (OR-0.53, 95% CI:0.32-0.86). Other polymorphisms were not associated either with MS susceptibility or with phenotype of the disease. No association with disability was found.
- We investigated the association of matrix metalloproteinase-9 (-1562C/T, +279R/Q) and matrix metalloproteinase-2 (-1575G/A, -1306C/T) gene polymorphisms with multiple sclerosis (MS) susceptibility, gender differences and disability in 244 patients and 132 healthy subjects. A significant decrease of the -1562T allele carriers in MS patients compared to controls (Pa=0.01, Pacorr=0.05) in -1562C/T MMP-9 gene polymorphism was found, (odds ratio (OR) -0.58, 95% confidence interval (CI):0.38-0.89). Significant differences were also demonstrated between female patients and healthy females (Pa=0.01, Pacorr=0.05), (OR-0.53, 95% CI:0.32-0.86). Other polymorphisms were not associated either with MS susceptibility or with phenotype of the disease. No association with disability was found. (en)
- Cílem studie bylo určit asociační vztah genetických polymorfismů (-1562C/T, +279 R/Q) v genu pro MMP-9 a (-1575G/A, -1306C/T) v genu pro matrix metalloproteinázu-2 s roztroušenou sklerózou (RS). Do studie bylo zařazeno 244 pacientů s RS, diagnostikovanou dle Mc Donaldových kriterií, kontrolní soubor byl tvořen 132 zdravými jedinci. Byl zjištěn signifikantní rozdíl genové distribuce (Pg= 0.03) a alelové frekvence (Pa=0.01, Pacorr=0,05) mezi skupinou pacientů s RS a zdravými jedinci v distribuci -1562C/T polymorfismu v genu pro MMP-9. Alela T se vyskytovala méně frekventně u pacientů s RS ( odds ratio (OR)=0.58, 95% confidential interval (CI): 0.38 -0.89). Signifaktní rozdíl byl též prokázán mezi skupinou žen s RS a zdravými ženami (Pa=0,01, Pacorr= 0,05), (OR- 0.53, 95% CI: 0.32 -0.86). Závěr: Byla nalezena signifikantní asociace polymorfismu (-1562C/T) C/v genu pro MMP-9 s vyšším rizikem rozvoje RS, zejména u žen. (cs)
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| Title
| - Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis.
- Asociace polymorfismů v genu pro matrix metalloproteinázu-9 a matrix metalloproteinázu-2 s roztroušenou sklerózou (cs)
- Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis. (en)
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| skos:prefLabel
| - Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis.
- Asociace polymorfismů v genu pro matrix metalloproteinázu-9 a matrix metalloproteinázu-2 s roztroušenou sklerózou (cs)
- Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis. (en)
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| skos:notation
| - RIV/65269705:_____/08:#0000180!RIV09-MZ0-65269705
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/65269705:_____/08:#0000180
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Neuroimmunology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bednařík, Josef
- Kadaňka, Zdeněk
- Novotná, Hana
- Štourač, Pavel
- Hladíková, Magdalena
- Benešová, Yvonne
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| http://linked.open...ain/vavai/riv/wos
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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