About: Dendritic Cell-based Immunotherapy for the Treatment of Hematological Malignancies

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About: Dendritic Cell-based Immunotherapy for the Treatment of Hematological Malignancies Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dendritic cells (DCs) are professional antigen-presenting cells and are frequently used in current immunotherapy protocols. The administration of DCs loaded with tumor associated proteins or peptides results in the induction of immune responses against different types of malignant cells. Method for large-scale generation of DCs in a sufficient quality and quantity have permitted their use in clinical experiments. DC-based vaccines have already shown promise in folicullar non-Hodgkin?s lymphoma, and some extent, in other hematological malignancies. Several strategies have been developed to boost their potency as a new and relatively non-toxic treatment modality. Our review focuses on clinical trials using DCs in the treatment of hematologic malignancies and on recent studies of the immunophenotype, development, and maturation of DCs may have an important impact on designing DC-based antitumor vaccines. Dendritic cells (DCs) are professional antigen-presenting cells and are frequently used in current immunotherapy protocols. The administration of DCs loaded with tumor associated proteins or peptides results in the induction of immune responses against different types of malignant cells. Method for large-scale generation of DCs in a sufficient quality and quantity have permitted their use in clinical experiments. DC-based vaccines have already shown promise in folicullar non-Hodgkin?s lymphoma, and some extent, in other hematological malignancies. Several strategies have been developed to boost their potency as a new and relatively non-toxic treatment modality. Our review focuses on clinical trials using DCs in the treatment of hematologic malignancies and on recent studies of the immunophenotype, development, and maturation of DCs may have an important impact on designing DC-based antitumor vaccines. (en)
Title	Dendritic Cell-based Immunotherapy for the Treatment of Hematological Malignancies Dendritic Cell-based Immunotherapy for the Treatment of Hematological Malignancies (en)
skos:prefLabel	Dendritic Cell-based Immunotherapy for the Treatment of Hematological Malignancies Dendritic Cell-based Immunotherapy for the Treatment of Hematological Malignancies (en)
skos:notation	RIV/65269705:_____/03:00007984!RIV/2004/MZ0/L43004/N
http://linked.open.../vavai/riv/strany	97-104
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ06526970501)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Büchler, Tomáš Michálek, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	603052
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/03:00007984
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Dendritic cells;Immunotherapy;Vaccination;Multiple myeloma;Lymphoma;Leukemia (en)
http://linked.open.../riv/klicoveSlovo	Immunotherapy Dendritic cells Multiple myeloma Lymphoma Leukemia Vaccination
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[140102641A4B]
http://linked.open...i/riv/nazevZdroje	Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Michálek, Jaroslav Büchler, Tomáš
http://linked.open...n/vavai/riv/zamer	General developement of the programs of highly specialited health care aiming cardiovaskular diseases, tumor diseases and perinatal medicine
issn	1024-5332
number of pages	8 (xsd:int)

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