About: COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells

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About: COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cyclooxygenases are key enzymes in the arachidonic acid metabolism. Their unstable intermediate, prostaglandin H(2), is further metabolized to bioactive lipids by various downstream enzymes. In this study, utilizing short hairpin RNAs, we prepared a cell line of human cervix carcinoma with stable down-regulated cyclooxygenase-1 (COX-1) to assess the impact of COX-1 reduction on the downstream enzymes. We found a significant microsomal prostaglandin E synthase-1 (mPGES-1) suppression. In addition, mRNA expression of multidrug resistance protein 4 (MRP4, ABCC4), supposed to take part in antiviral and anticancer drug transport from cells, was up-regulated after COX-1 down-regulation. Our findings indicate that mPGES-1, believed to be coexpressed preferentially with cyclooxygenase-2, may be coupled to COX-1. ABCC4 up-regulation further supports the assumption of its involvement in prostanoid transport. Cyclooxygenases are key enzymes in the arachidonic acid metabolism. Their unstable intermediate, prostaglandin H(2), is further metabolized to bioactive lipids by various downstream enzymes. In this study, utilizing short hairpin RNAs, we prepared a cell line of human cervix carcinoma with stable down-regulated cyclooxygenase-1 (COX-1) to assess the impact of COX-1 reduction on the downstream enzymes. We found a significant microsomal prostaglandin E synthase-1 (mPGES-1) suppression. In addition, mRNA expression of multidrug resistance protein 4 (MRP4, ABCC4), supposed to take part in antiviral and anticancer drug transport from cells, was up-regulated after COX-1 down-regulation. Our findings indicate that mPGES-1, believed to be coexpressed preferentially with cyclooxygenase-2, may be coupled to COX-1. ABCC4 up-regulation further supports the assumption of its involvement in prostanoid transport. (en)
Title	COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells (en)
skos:prefLabel	COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells (en)
skos:notation	RIV/63221667:_____/09:#0000026!RIV10-MZ0-63221667
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(NR8760), S, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kunc, Filip Šafářová, Martina Holasová, Šárka Víšková, Alena Radilová, Hana Libra, Antonín Bunček, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	GENERI BIOTECH s.r.o.
http://linked.open...dnocenehoVysledku	308469
http://linked.open...ai/riv/idVysledku	RIV/63221667:_____/09:#0000026
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cyclooxygenase; Prostaglandin E synthase; mPGES-1; Multidrug resistance protein; ABCC4; shRNA (en)
http://linked.open.../riv/klicoveSlovo	ABCC4 Cyclooxygenase Multidrug resistance protein Prostaglandin E synthase mPGES-1 shRNA
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[BFD3F5D7A9C0]
http://linked.open...i/riv/nazevZdroje	Mol Cell Biochem
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Cyclooxygenases: down-regulation and the influence on the gene expression
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	330
http://linked.open...iv/tvurceVysledku	Bunček, Martin Libra, Antonín Víšková, Alena Kunc, Filip Radilová, Hana Holasová, Šárka Šafářová, Martina
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0300-8177
number of pages	10 (xsd:int)

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