About: Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat

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About: Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Breast cancer resistance protein (BCRP/ABCG2) is an ABC family drug efflux transporter expressed in a number of physiological tissues including placenta. Here we investigated the expression and function of Bcrp in the rat placenta and fetus during pregnancy. We show that the expression of Bcrp mRNA in placenta peaks on gestation day (gd) 15 and declines significantly to one third up to term. In fetal body tissue, 6.9 and 7.4-fold Bcrp mRNA increase was detected on gds 15 and 18, respectively, compared to the early gd 12. The expression of Bcrp mRNA in fetal organs on gds 18 and 21 is also demonstrated. Additionally, the function of placental and fetal Bcrp during pregnancy was studied by fetal exposure to cimetidine infused to the maternal circulation. The relative amount of drug that penetrated to fetus was highest on gd 12 and decreased to one tenth thereafter. Breast cancer resistance protein (BCRP/ABCG2) is an ABC family drug efflux transporter expressed in a number of physiological tissues including placenta. Here we investigated the expression and function of Bcrp in the rat placenta and fetus during pregnancy. We show that the expression of Bcrp mRNA in placenta peaks on gestation day (gd) 15 and declines significantly to one third up to term. In fetal body tissue, 6.9 and 7.4-fold Bcrp mRNA increase was detected on gds 15 and 18, respectively, compared to the early gd 12. The expression of Bcrp mRNA in fetal organs on gds 18 and 21 is also demonstrated. Additionally, the function of placental and fetal Bcrp during pregnancy was studied by fetal exposure to cimetidine infused to the maternal circulation. The relative amount of drug that penetrated to fetus was highest on gd 12 and decreased to one tenth thereafter. (en)
Title	Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat (en)
skos:prefLabel	Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat (en)
skos:notation	RIV/63221667:_____/08:#0000023!RIV10-MZ0-63221667
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(1A8696), S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Štaud, František Novotná, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	GENERI BIOTECH s.r.o.
http://linked.open...dnocenehoVysledku	393163
http://linked.open...ai/riv/idVysledku	RIV/63221667:_____/08:#0000023
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Breast cancer resistance protein; Placenta; Gene expression; Rat; Pregnancy (en)
http://linked.open.../riv/klicoveSlovo	Gene expression Pregnancy Rat Breast cancer resistance protein Placenta
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CC40DF1CBF79]
http://linked.open...i/riv/nazevZdroje	Toxicology Letters
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	In-vitro study of molecular-genetic cuase of cell resistance against selected drugs
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	178
http://linked.open...iv/tvurceVysledku	Pávek, Petr Čečková, Martina Štaud, František Cygalová, Lenka
issn	0378-4274
number of pages	5 (xsd:int)

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