About: Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.benthamscience.com/contents.php?in=108957&m=May&y=2013
Description	K203 is an experimental bis-pyridinium mono-aldoxime type cholinesterase reactivator of potential use in organophosphate/organophosphonate poisoning. Pharmacokinetics of K203 were examined in Wistar rats and beagle dogs using ion-pair HPLC. Serum and cerebrospinal fluid concentrations of K203 were determined using ion-pair reversed-phase chromatography on octadecyl silica column. HPLC with ultraviolet detection was used for determination of serum concentration of K203 higher than 0.1 mu g/mL while its low concentrations in cerebrospinal fluid required electrochemical detection (0.015 through 4 mu g/mL range). In rats the serum levels of K203 followed zero order pharmacokinetics from 15 to 120 minutes post administration. Zero order pharmacokinetics was also observed in beagle dogs after low dose (15 mu mol/kg) of K203 administration. High dose administration (250 mu mol/kg) led to subsequent hindered elimination from both cerebrospinal fluid and serum. K203 is an experimental bis-pyridinium mono-aldoxime type cholinesterase reactivator of potential use in organophosphate/organophosphonate poisoning. Pharmacokinetics of K203 were examined in Wistar rats and beagle dogs using ion-pair HPLC. Serum and cerebrospinal fluid concentrations of K203 were determined using ion-pair reversed-phase chromatography on octadecyl silica column. HPLC with ultraviolet detection was used for determination of serum concentration of K203 higher than 0.1 mu g/mL while its low concentrations in cerebrospinal fluid required electrochemical detection (0.015 through 4 mu g/mL range). In rats the serum levels of K203 followed zero order pharmacokinetics from 15 to 120 minutes post administration. Zero order pharmacokinetics was also observed in beagle dogs after low dose (15 mu mol/kg) of K203 administration. High dose administration (250 mu mol/kg) led to subsequent hindered elimination from both cerebrospinal fluid and serum. (en)
Title	Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs (en)
skos:prefLabel	Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs (en)
skos:notation	RIV/62690094:18470/13:50001680!RIV14-MSM-18470___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	16
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Hradec Králové / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	108810
http://linked.open...ai/riv/idVysledku	RIV/62690094:18470/13:50001680
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	UV detection; serum level; rats; pharmacokinetics; K203; HPLC; beagle dogs; Amperometric detection (en)
http://linked.open.../riv/klicoveSlovo	UV detection beagle dogs serum level Amperometric detection HPLC K203 pharmacokinetics rats
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DCBCBDF21CF0]
http://linked.open...i/riv/nazevZdroje	Current medicinal chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Musílek, Kamil Balogh, L. Kalasz, H. Szegi, P. Tekes, K. Janoki, G. Petroianu, G. A. Poestenyi, Z. Siddiq, A.
http://linked.open...ain/vavai/riv/wos	000317662200006
issn	0929-8673
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/0929867311320160006
http://localhost/t...ganizacniJednotka	18470

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