About: Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

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About: Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pub.iapchem.org/ojs/index.php/admet/article/download/26/48
Description	The investigation deals with the affection of permeation of mupirocin from the Bactroban(R) Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the permeation of mupirocin within 1 h after administration (approx. 5-fold). On the other hand, nanonized alaptide almost completely inhibited permeation of mupirocin from Bactroban(R) Leciva through the skin. Rapid primary screening showed that the two forms of alaptide differently influenced the depth and the rate of permeation/penetration of mupirocin into/through the skin, i.e., affect curative effect of mupirocin on/in skin immediately after application of drug formulation. The investigation deals with the affection of permeation of mupirocin from the Bactroban(R) Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the permeation of mupirocin within 1 h after administration (approx. 5-fold). On the other hand, nanonized alaptide almost completely inhibited permeation of mupirocin from Bactroban(R) Leciva through the skin. Rapid primary screening showed that the two forms of alaptide differently influenced the depth and the rate of permeation/penetration of mupirocin into/through the skin, i.e., affect curative effect of mupirocin on/in skin immediately after application of drug formulation. (en)
Title	Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide (en)
skos:prefLabel	Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide (en)
skos:notation	RIV/62157124:16370/14:43873238!RIV15-GA0-16370___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/11/2246)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Jampílek, Josef Opatřilová, R.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	41363
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/14:43873238
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Bactroban; nanoparticles; mupirocin; alaptide (en)
http://linked.open.../riv/klicoveSlovo	nanoparticles alaptide Bactroban mupirocin
http://linked.open...odStatuVydavatele	HR - Chorvatská republika
http://linked.open...ontrolniKodProRIV	[EA51CB17A93A]
http://linked.open...i/riv/nazevZdroje	ADMET & DMPK
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Jampílek, Josef Opatřilová, Radka
issn	1848-7718
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.5599/admet.2.1.26
http://localhost/t...ganizacniJednotka	16370

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