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rdf:type
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Description
| - Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7b,6b-dihydroxyroyleanone (2), 7b-acetoxy-6b-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and a-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alfa-glucosidase with IC50 values from 33 to 275 mikroM. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
- Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7b,6b-dihydroxyroyleanone (2), 7b-acetoxy-6b-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and a-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alfa-glucosidase with IC50 values from 33 to 275 mikroM. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis. (en)
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Title
| - Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
- Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth (en)
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skos:prefLabel
| - Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
- Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth (en)
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skos:notation
| - RIV/62157124:16370/14:43872753!RIV15-MSM-16370___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16370/14:43872753
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - rosmarinic acid; diterpenoids; cholinesterase; antibacterial activity; alfa-glucosidase (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Enzyme Inhibition and Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kubínová, Renáta
- Valentová, Marie
- Čížek, Alois
- Farsa, Oldřich
- Navrátilová, Alice
- Hanáková, Zuzana
- Pořízková, Radka
- Bačinská, Adriana
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.3109/14756366.2013.848204
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http://localhost/t...ganizacniJednotka
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