| Attributes | Values |
|---|
| rdf:type
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| Description
| - The original esters of meta-/para-alkoxyphenylcarbamic acid containing 4-(2-methyl-/2-fluorophenyl)piperazin-1-yl, labelled as 5d-7d, were screened for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, respectively. Following the minimum inhibitory concentration (MIC) assay, electronic and hydrophobic interactions, induced by suitable substitution at the N-phenylpiperazine, ring have appeared to be more noticabe factors which positively influenced the efficiency of these compounds against S. aureus as well as against E. coli than relatively high lipophilicity of 5d-7d. In general, the compounds comprising methyl substituent attached to basic fragment (7a-7d) were observed to be more active against both given bacterial strains in the comparison to those with fluoro group (5d and 5e). From the entire analyzed set, the most active molecule 7b showed MIC=0.10 mg.mL(-1) against given Gram-positive and Gram-negative bacteria as well. On the contrary, the increase in evaluated molecules lipophilicity accompanied by the presence of the substituent at N-phenylpiperazine with primarily strong electron-donating or a slightly electron-withdrawing effect has not positively reflected in their efficiency against C. albicans (MICs}1.00 mg.mL(-1)).
- The original esters of meta-/para-alkoxyphenylcarbamic acid containing 4-(2-methyl-/2-fluorophenyl)piperazin-1-yl, labelled as 5d-7d, were screened for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, respectively. Following the minimum inhibitory concentration (MIC) assay, electronic and hydrophobic interactions, induced by suitable substitution at the N-phenylpiperazine, ring have appeared to be more noticabe factors which positively influenced the efficiency of these compounds against S. aureus as well as against E. coli than relatively high lipophilicity of 5d-7d. In general, the compounds comprising methyl substituent attached to basic fragment (7a-7d) were observed to be more active against both given bacterial strains in the comparison to those with fluoro group (5d and 5e). From the entire analyzed set, the most active molecule 7b showed MIC=0.10 mg.mL(-1) against given Gram-positive and Gram-negative bacteria as well. On the contrary, the increase in evaluated molecules lipophilicity accompanied by the presence of the substituent at N-phenylpiperazine with primarily strong electron-donating or a slightly electron-withdrawing effect has not positively reflected in their efficiency against C. albicans (MICs}1.00 mg.mL(-1)). (en)
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| Title
| - BASIC ESTERS OF meta-/para-ALKOXYPHENYLCARBAMIC ACID CONTAINING 4-(2-METHYL-/2-FLUOROPHENYL)PIPERAZIN-1-YL MOIETY AND THEIR ANTIMICROBIAL ACTIVITY
- BASIC ESTERS OF meta-/para-ALKOXYPHENYLCARBAMIC ACID CONTAINING 4-(2-METHYL-/2-FLUOROPHENYL)PIPERAZIN-1-YL MOIETY AND THEIR ANTIMICROBIAL ACTIVITY (en)
|
| skos:prefLabel
| - BASIC ESTERS OF meta-/para-ALKOXYPHENYLCARBAMIC ACID CONTAINING 4-(2-METHYL-/2-FLUOROPHENYL)PIPERAZIN-1-YL MOIETY AND THEIR ANTIMICROBIAL ACTIVITY
- BASIC ESTERS OF meta-/para-ALKOXYPHENYLCARBAMIC ACID CONTAINING 4-(2-METHYL-/2-FLUOROPHENYL)PIPERAZIN-1-YL MOIETY AND THEIR ANTIMICROBIAL ACTIVITY (en)
|
| skos:notation
| - RIV/62157124:16370/13:43872345!RIV14-MSM-16370___
|
| http://linked.open...avai/predkladatel
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16370/13:43872345
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Escherichia coil; Staphylococcus aureus; substituted N-phenylpiperazine; phenylcarbamates (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Fresenius Environmental Bulletin
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Csöllei, Jozef
- Malík, Ivan
- Sedlárová, Eva
- Bukovský, Marián
- Sichrovská, Lubica
|
| http://linked.open...ain/vavai/riv/wos
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
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