About: In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name %22alaptide,%22 in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the permeation of alaptide through artificial or biological membranes, such as PAMPA or skin. The permeation of micronized and nanonized form of alaptide formulated to various semisolid pharmaceutical compositions through full-thickness pig ear skin using a Franz cell has been investigated in detail. In general, it can be concluded that the nanonized alaptide permeated through the skin less than the micronized form; different observations were made for permeation through the PAMPA system, where the micronized form showed lower permeation than the nanonized alaptide. This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name %22alaptide,%22 in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the permeation of alaptide through artificial or biological membranes, such as PAMPA or skin. The permeation of micronized and nanonized form of alaptide formulated to various semisolid pharmaceutical compositions through full-thickness pig ear skin using a Franz cell has been investigated in detail. In general, it can be concluded that the nanonized alaptide permeated through the skin less than the micronized form; different observations were made for permeation through the PAMPA system, where the micronized form showed lower permeation than the nanonized alaptide. (en)
Title	In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations (en)
skos:prefLabel	In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations (en)
skos:notation	RIV/62157124:16370/13:43872238!RIV14-GA0-16370___
http://linked.open...avai/predkladatel	Farmaceutická fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP304/11/2246)
http://linked.open...iv/cisloPeriodika	2013
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Černíková, Aneta Jampílek, Josef Opatřilová, R. Dohnal, Jiří Dvořáková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	79410
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/13:43872238
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	rats; delivery; dipeptides; nanomaterials; model; absorption; nanoparticles; ear skin; human skin; leucyl-glycinamide (en)
http://linked.open.../riv/klicoveSlovo	human skin absorption model nanoparticles dipeptides ear skin leucyl-glycinamide nanomaterials rats delivery
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D1D89083F89A]
http://linked.open...i/riv/nazevZdroje	Scientific World Journal
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	neuveden
http://linked.open...iv/tvurceVysledku	Dohnal, Jiří Jampílek, Josef Opatřilová, Radka Coufalová, Lenka Černíková, Aneta
http://linked.open...ain/vavai/riv/wos	000329048400001
issn	1537-744X
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2013/787283
http://localhost/t...ganizacniJednotka	16370

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