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  • Three cationic acrylic polymers, i. e. Eudragit RL, Eudragit RS and Eudragit E 100 were evaluated for the purpose of microparticles preparation by the solvent evaporation method. Practically insoluble drug mirtazapine and freely soluble drug tramadol hydrochloride were selected for encapsulation as extreme limits of drug solubility. Prepared microspheres were analyzed by optical microscopy, drug content analysis and dissolution test. It was observed that Eudragit RL did not provide microparticles while Eudragit RS and Eudragit E 100 gave spherical microparticles. Samples prepared with mirtazapine showed sustained drug release whereas tramadol hydrochloride samples released the drug in a pattern similar to immediate release profile. Eudragit RS was found to be superior to Eudragit E 100 in its encapsulation efficiency, drug loading and smaller mean size of microparticles.
  • Three cationic acrylic polymers, i. e. Eudragit RL, Eudragit RS and Eudragit E 100 were evaluated for the purpose of microparticles preparation by the solvent evaporation method. Practically insoluble drug mirtazapine and freely soluble drug tramadol hydrochloride were selected for encapsulation as extreme limits of drug solubility. Prepared microspheres were analyzed by optical microscopy, drug content analysis and dissolution test. It was observed that Eudragit RL did not provide microparticles while Eudragit RS and Eudragit E 100 gave spherical microparticles. Samples prepared with mirtazapine showed sustained drug release whereas tramadol hydrochloride samples released the drug in a pattern similar to immediate release profile. Eudragit RS was found to be superior to Eudragit E 100 in its encapsulation efficiency, drug loading and smaller mean size of microparticles. (en)
Title
  • Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method
  • Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method (en)
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  • Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method
  • Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method (en)
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  • RIV/62157124:16370/13:43872056!RIV14-MSM-16370___
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  • RIV/62157124:16370/13:43872056
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  • microparticles, solvent evaporation, sustained drug release, Eudragit? (en)
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  • 62
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  • Dvořáčková, Kateřina
  • Vetchý, David
  • Kejdušová, Martina
  • Bavoľárová, Jana
  • Vysloužil, Jakub
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