About: Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release

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About: Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	PLGA microparticles for sustained release of ibuprofen as the model drug were prepared by O/W solvent evaporation method under altering stirring speed (600, 1000 rpm), emulsifier concentration (PVA concentration 0.1%, 1%) and organic solvent selection (dichloromethane, ethyl acetate). Obtained results confirmed the effect of selected formulation and process parameters on properties of prepared PLGA-based microparticles. The influence on encapsulation efficiency, yield, morphological properties, mean size and drug release was observed. The increased stirring speed within the solvent evaporation process led to decrease of encapsulation efficiency, yield and mean size but incorporated drug was released faster. Increased PVA concentration in external emulsion phase brought same results except ibuprofen release rate. Microparticles prepared with dichloromethane as the organic solvent exhibit higher sphericity, more regular shape with smooth surface, thus dichloromethane was considered as more suitable organic solvent in comparison to ethyl acetate for this purpose. PLGA microparticles for sustained release of ibuprofen as the model drug were prepared by O/W solvent evaporation method under altering stirring speed (600, 1000 rpm), emulsifier concentration (PVA concentration 0.1%, 1%) and organic solvent selection (dichloromethane, ethyl acetate). Obtained results confirmed the effect of selected formulation and process parameters on properties of prepared PLGA-based microparticles. The influence on encapsulation efficiency, yield, morphological properties, mean size and drug release was observed. The increased stirring speed within the solvent evaporation process led to decrease of encapsulation efficiency, yield and mean size but incorporated drug was released faster. Increased PVA concentration in external emulsion phase brought same results except ibuprofen release rate. Microparticles prepared with dichloromethane as the organic solvent exhibit higher sphericity, more regular shape with smooth surface, thus dichloromethane was considered as more suitable organic solvent in comparison to ethyl acetate for this purpose. (en)
Title	Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release (en)
skos:prefLabel	Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release Influence of formulation and process parameters on characteristics of PLGA-based microparticles with controlled drug release (en)
skos:notation	RIV/62157124:16370/13:43872054!RIV14-MSM-16370___
http://linked.open...avai/predkladatel	Farmaceutická fakulta
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vysloužil, Jakub Dvořáčková, Kateřina Bajerová, Martina Vetchý, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	79770
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/13:43872054
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microparticles, solvent evaporation, PLGA, controlled release, burst effect (en)
http://linked.open.../riv/klicoveSlovo	microparticles PLGA burst effect controlled release solvent evaporation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[468A382742A9]
http://linked.open...i/riv/nazevZdroje	Česká a slovenská farmacie
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Dvořáčková, Kateřina Vetchý, David Kejdušová, Martina Vysloužil, Jakub
issn	1210-7816
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	16370

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