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  • The pellets containing rutin prepared by extrusion/ spheronization method were coated with natrium alginate - chitosan film. Important quality parameters in pellets before the coating were determined, and after the coating dissolution profiles of the drug were evaluated in dissolution media of pH corresponding to the conditions in gastrointestinal tract. Samples of coated pellets were located in the boxes for stability testing under different conditions, i.e. 25 °C and 60 % of relative humidity (RH); 30 °C and 65 % RH and 40 °C and 75 % RH. After 1, 3, 6, 9 and 12 months (or 1, 3 and 6 months), dissolution test was repeated and compared with the original profiles using similarity factors. All similarity factor values above 50 indicate excellent stability of alginate-chitosan films.
  • The pellets containing rutin prepared by extrusion/ spheronization method were coated with natrium alginate - chitosan film. Important quality parameters in pellets before the coating were determined, and after the coating dissolution profiles of the drug were evaluated in dissolution media of pH corresponding to the conditions in gastrointestinal tract. Samples of coated pellets were located in the boxes for stability testing under different conditions, i.e. 25 °C and 60 % of relative humidity (RH); 30 °C and 65 % RH and 40 °C and 75 % RH. After 1, 3, 6, 9 and 12 months (or 1, 3 and 6 months), dissolution test was repeated and compared with the original profiles using similarity factors. All similarity factor values above 50 indicate excellent stability of alginate-chitosan films. (en)
Title
  • Stability testing of alginate-chitosan films
  • Stability testing of alginate-chitosan films (en)
skos:prefLabel
  • Stability testing of alginate-chitosan films
  • Stability testing of alginate-chitosan films (en)
skos:notation
  • RIV/62157124:16370/12:43871091!RIV13-MSM-16370___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 170831
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/12:43871091
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • alginate, chitosan, films, colon drug delivery, stability (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [5A682BBAE22C]
http://linked.open...i/riv/nazevZdroje
  • Česká a slovenská farmacie
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 61
http://linked.open...iv/tvurceVysledku
  • Dvořáčková, Kateřina
  • Rabišková, Miloslava
  • Kofroňová, Lenka
issn
  • 1210-7816
number of pages
http://localhost/t...ganizacniJednotka
  • 16370
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