About: Contribution to investigation of antimicrobial activity of styrylquinolines

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed. (C) 2012 Elsevier Ltd. All rights reserved. Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed. (C) 2012 Elsevier Ltd. All rights reserved. (en)
Title	Contribution to investigation of antimicrobial activity of styrylquinolines Contribution to investigation of antimicrobial activity of styrylquinolines (en)
skos:prefLabel	Contribution to investigation of antimicrobial activity of styrylquinolines Contribution to investigation of antimicrobial activity of styrylquinolines (en)
skos:notation	RIV/62157124:16370/12:43871087!RIV13-MSM-16370___
http://linked.open...avai/predkladatel	Farmaceutická fakulta
http://linked.open...avai/riv/aktivita	I V
http://linked.open...avai/riv/aktivity	I, V
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Jampílek, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	128658
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/12:43871087
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Structure-activity relationships; In vitro antibacterial activity; In vitro antifungal activity; Quinolines lipophilicity (en)
http://linked.open.../riv/klicoveSlovo	In vitro antifungal activity Structure-activity relationships In vitro antibacterial activity Quinolines lipophilicity
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[E0231D32C48B]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Jampílek, Josef Vejšová, Marcela Cieslik, Wioleta Machura, Barbara Musiol, Robert Nycz, Jacek E Polanski, Jaroslaw Wolff, Mariusz
http://linked.open...ain/vavai/riv/wos	000311421300007
issn	0968-0896
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bmc.2012.10.027
http://localhost/t...ganizacniJednotka	16370
is http://linked.open...avai/riv/vysledek of	Contribution to investigation of antimicrobial activity of styrylquinolines

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