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| Description
| - The present paper aims at a complex spectral and physicochemical evaluation of mono[{3-[4-(2-ethoxyethoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammonium] fumarate, the potential ultra-short acting blocker of ß1-adrenergic receptors. The identity of the evaluated compound (labelled as UPB-2) was confirmed by 1H-, 13C-NMR and IR spectral data as well. The estimated physicochemical parameters included melting point data, solubility in variol media, purity checking (adsorption thin-layer chromatography), surface activity determination (non-direct Traube stalagmometric method), acidobasic characteristics (pKa value determination by alkalimetric titration), log epsilon values estimation (spectrophotometrically in UV/VIS region) and a study of the influence of acidic and alkaline media towards the stability of UPB-2. Other experimentally estimated values were lipohydrophilic descriptors using RP- HPLC (log k') and the log Pexps in variol lipohydrophilic media by the shake flask method. Based on the log Pexp readouts, the ability to permeate across the brain-blood barrier was predicted. For the content determination of UBP-2 the RP-HPLC (reversed-phase HPLC), the method of an internal standard and UV/VIS spectrophotometry at the wavelength of 260 nm (aqueous medium) and at 258 nm (methanolic medium) was applied. (en)
- Predmetom publikácie je komplexné spektrálne a fyzikálno-chemické hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-terc-butylamónium]fumarátu, potenciálneho ultrakrátko pôsobiaceho blokátora ß1-adrenergných receptorov. Totožnosť hodnotenej zlúčeniny (pracovne označenej ako UPB-2) bola potvrdená 1H-, 13C-NMR a IR spektrami. V rámci stanovenia základných fyzikálno-chemických charakteristík bola určená hodnota teploty topenia, rozpustnosť v spektre rozpúšťadiel, čistota (adsorpčná chromatografia na tenkej vrstve), povrchová aktivita (nepriama Traubeho stalagmometrická metóda), acidobázické charakteristiky (hodnota pKa stanovená alkalimetrickou titráciou), hodnoty log epsilon (spektrofotometricky v UV/ /VIS oblasti), ako aj hodnotenie vplyvu kyslého a zásaditého prostredia na stabilitu UPB-2. Ďalšími experimentálne stanovenými parametrami boli lipohydrofilné deskriptory určené pomocou RP-HPLC (log k'), shake flask metódou stanovené hodnoty rozdeľovacích koeficientov Pexp (resp. log Pexp) v rôznych rozdeľovacích systémoch. Na základe log Pexp-údajov bola predpovedaná schopnosť UPB-2 prechádzať cez hematoencefalickú bariéru. Pre stanovenie obsahu UPB-2 bola aplikovaná RP HPLC (reversed-phase HPLC) metóda vnútorného štandardu a UV/VIS spektrofotometria pri vlnovej dĺžke 260 nm (vodné prostredie) a 258 nm (prostredie metanolu).
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| Title
| - Analytical evaluation of mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammonium]fumarate (en)
- Analytické hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammónium]fumarátu
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| skos:prefLabel
| - Analytical evaluation of mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammonium]fumarate (en)
- Analytické hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammónium]fumarátu
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| skos:notation
| - RIV/62157124:16370/12:43871026!RIV13-MSM-16370___
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16370/12:43871026
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - content determinativ; spectral and physicochemical properties; analytical evaluation; ß1-blockers (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Česká a slovenská farmacie
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Andriamainty, Fils
- Csöllei, Jozef
- Gališinová, Jana
- Karlovská, Janka
- Lukáč, Miloš
- Malík, Ivan
- Mokrý, Petr
- Mitterová, Lenka
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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