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  • Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from Schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-gamma-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-gomisin P, (-)-wuweizisu C, (-)-gomisin D, rubrisandrin A, (-)-gomisin G, (+)-gomisin K-3 and (-)-schisantherin C. A full NMR description of (-)-schisantherin C was carried out with the aim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, H-1- and C-13-NMR and MS. The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested.
  • Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from Schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-gamma-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-gomisin P, (-)-wuweizisu C, (-)-gomisin D, rubrisandrin A, (-)-gomisin G, (+)-gomisin K-3 and (-)-schisantherin C. A full NMR description of (-)-schisantherin C was carried out with the aim to confirm previous reports of its structure. Compounds isolated were identified on the basis of UV, IR, H-1- and C-13-NMR and MS. The cytotoxicity of lignans was tested for the BY-2 cell line alone and as a synergistic effect with the cytotoxic agent camptothecin. Lignans showed various toxicity and synergistic and antagonistic effects on camptothecin-induced cytotoxicity. Cytotoxicity against colon cancer cell line LoVo was also tested. (en)
Title
  • Evaluation of Cytotoxic Activity of Schisandra chinensis Lignans
  • Evaluation of Cytotoxic Activity of Schisandra chinensis Lignans (en)
skos:prefLabel
  • Evaluation of Cytotoxic Activity of Schisandra chinensis Lignans
  • Evaluation of Cytotoxic Activity of Schisandra chinensis Lignans (en)
skos:notation
  • RIV/62157124:16370/10:00002607!RIV11-GA0-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1A8666), P(GA522/07/0995), S
http://linked.open...iv/cisloPeriodika
  • 15
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 257821
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/10:00002607
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Schisandra chinensis; Schisandraceae; dibenzocyclooctadiene lignans; cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [E73B57DF12F7]
http://linked.open...i/riv/nazevZdroje
  • Planta Medica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 76
http://linked.open...iv/tvurceVysledku
  • Babula, Petr
  • Šmejkal, Karel
  • Dall'Acqua, Stefano
  • Vančo, Ján
  • Urbanová, Marie
  • Julínek, Ondřej
  • Slanina, Jiří
  • Innocenti, Gabbriella
  • Šlapetová, Tereza
  • Kramářová, Eva
  • Dvorská, Margita
  • Krmenčík, Pavel
  • Carrara, Maria
  • Casarin, Elisabetta
  • Kalvarová, Karolina
http://linked.open...ain/vavai/riv/wos
  • 000283917300007
issn
  • 0032-0943
number of pages
http://localhost/t...ganizacniJednotka
  • 16370
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