About: Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	OBJECTIVES: Our study aims to find the relationship between metabolic enzyme thiopurine S-methyltransferase (TPMT) gene polymorphisms and clinical output of the therapy with azathioprine. We focused on patients who experienced leucopenia caused by high blood levels of active azathioprine metabolites. DESIGN: Our group consists of 87 patients who have been treated by azathioprine. 21 individuals experienced leucopenia during treatment with standard dose of azathioprine. We have used PCR-REA and real-time PCR methods for genotype detection G238C, G460G and A719G substitutions in TPMT gene. RESULTS: We have found statistical association between the presence of non-standard TPMT alleles and adverse event associated with azathioprine treatment leucopenia (p=0.0033). CONCLUSION: Our results confirm that TPMT genotyping prior to the treatment with azathioprine could predict patients with genetic predisposition for serious leucopenia and seems to be a useful genetic marker for individualisation of the therapy OBJECTIVES: Our study aims to find the relationship between metabolic enzyme thiopurine S-methyltransferase (TPMT) gene polymorphisms and clinical output of the therapy with azathioprine. We focused on patients who experienced leucopenia caused by high blood levels of active azathioprine metabolites. DESIGN: Our group consists of 87 patients who have been treated by azathioprine. 21 individuals experienced leucopenia during treatment with standard dose of azathioprine. We have used PCR-REA and real-time PCR methods for genotype detection G238C, G460G and A719G substitutions in TPMT gene. RESULTS: We have found statistical association between the presence of non-standard TPMT alleles and adverse event associated with azathioprine treatment leucopenia (p=0.0033). CONCLUSION: Our results confirm that TPMT genotyping prior to the treatment with azathioprine could predict patients with genetic predisposition for serious leucopenia and seems to be a useful genetic marker for individualisation of the therapy (en)
Title	Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity (en)
skos:prefLabel	Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity (en)
skos:notation	RIV/62157124:16370/09:00002115!RIV10-MZ0-16370___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9342)
http://linked.open...iv/cisloPeriodika	Suppl.1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hošek, Jan Bartošová, L.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	318793
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/09:00002115
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	azathioprine; inflammatory bowel disease (IBD); thiopurine S-methyltransferase (TPMT); pharmacogenetics; leucopenia (en)
http://linked.open.../riv/klicoveSlovo	azathioprine pharmacogenetics leucopenia inflammatory bowel disease (IBD) thiopurine S-methyltransferase (TPMT)
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[7D5AB090D421]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic Polymorphisms in Connection with Clinical Forms of Crohn´s Disease and it´s Response to Treatment
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Hošek, Jan Zbořil, Vladimír Bartošová, Ladislava Kolorz, Michal Chýlková, Alicja Bátovský, Marian Dvořáčková, Dana
http://linked.open...ain/vavai/riv/wos	000275266600027
issn	0172-780X
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	16370
is http://linked.open...avai/riv/vysledek of	Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity Importance of Thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity

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