Attributes | Values |
---|
rdf:type
| |
Description
| - The purpose of this experimental work was the development of hydrophilic - lipophilic matrix tablets for controlled release of slightly soluble drug represented here by diclofenac sodium. Drug dissolution profile optimization provided by soluble filler was studied. Matrix tablets were based on cetyl alcohol as the lipophilic carrier, povidone as the gel forming agent, and common soluble filler, i.e. lactose or sucrose of different particle size. Physical properties of tablets prepared by melt granulation and drug release in a phosphate buffer of pH 6.8 were evaluated. In vitro studies showed that used the filler type, filler to povidone ratio and sucrose particle size influenced the drug release rate. Diclofenac sodium dissolution profile could be changed within a wide range from about 50 % per 24 hours to almost 100 % in 10 hours. The release constant values confirmed that diclofenac sodium was released from matrices by the diffusion and anomalous transport. The influence of sucrose particle size on
- The purpose of this experimental work was the development of hydrophilic - lipophilic matrix tablets for controlled release of slightly soluble drug represented here by diclofenac sodium. Drug dissolution profile optimization provided by soluble filler was studied. Matrix tablets were based on cetyl alcohol as the lipophilic carrier, povidone as the gel forming agent, and common soluble filler, i.e. lactose or sucrose of different particle size. Physical properties of tablets prepared by melt granulation and drug release in a phosphate buffer of pH 6.8 were evaluated. In vitro studies showed that used the filler type, filler to povidone ratio and sucrose particle size influenced the drug release rate. Diclofenac sodium dissolution profile could be changed within a wide range from about 50 % per 24 hours to almost 100 % in 10 hours. The release constant values confirmed that diclofenac sodium was released from matrices by the diffusion and anomalous transport. The influence of sucrose particle size on (en)
|
Title
| - Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets
- Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets (en)
|
skos:prefLabel
| - Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets
- Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets (en)
|
skos:notation
| - RIV/62157124:16370/09:00002097!RIV10-MSM-16370___
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| |
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16370/09:00002097
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - matrix tablets; diclofenac sodium; fillers; particle size; drug release; release mechanism (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| - Drug Development and Industrial Pharmacy
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Dvořáčková, Kateřina
- Muselík, Jan
- Rabišková, Miloslava
- Masteiková, Ruta
- Krejčová, Kateřina
|
http://linked.open...ain/vavai/riv/wos
| |
issn
| |
number of pages
| |
http://localhost/t...ganizacniJednotka
| |
is http://linked.open...avai/riv/vysledek
of | |