About: Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider     Goto   Sponge   NotDistinct   Permalink

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  • We have investigated anticholinesterase potential of the methanol extracts from the leaf, wood, flower, twig, and stem bark of the female and male individuals and rhizodermis and fruit from the female tree of Maclura pomifera (Rafin.) Schneider (Moraceae) along with its major isoflavonoids; osajin and pomiferin as well as their semi-synthetic derivatives; iso-osajin and iso-pomiferin. Anticholinesterase activity was determined by Ellman method using ELISA microplate reader. Osajin and pomiferin had a noticeable inhibition of AChE with IC(50) values of 2.239 and 0.096 mM, respectively, while their iso-derivatives were found to display less inhibition towards AChE. The extracts and compounds did not inhibit BChE. The extracts were analyzed for osajin and pomiferin contents by LC-DAD-MS and only the fruits and female flowers contained osajin (fruit: 8.87%, female flowers: 0.19%, w/w) and pomiferin (fruit: 13.6%, female flowers: 0.36%, w/w).
  • We have investigated anticholinesterase potential of the methanol extracts from the leaf, wood, flower, twig, and stem bark of the female and male individuals and rhizodermis and fruit from the female tree of Maclura pomifera (Rafin.) Schneider (Moraceae) along with its major isoflavonoids; osajin and pomiferin as well as their semi-synthetic derivatives; iso-osajin and iso-pomiferin. Anticholinesterase activity was determined by Ellman method using ELISA microplate reader. Osajin and pomiferin had a noticeable inhibition of AChE with IC(50) values of 2.239 and 0.096 mM, respectively, while their iso-derivatives were found to display less inhibition towards AChE. The extracts and compounds did not inhibit BChE. The extracts were analyzed for osajin and pomiferin contents by LC-DAD-MS and only the fruits and female flowers contained osajin (fruit: 8.87%, female flowers: 0.19%, w/w) and pomiferin (fruit: 13.6%, female flowers: 0.36%, w/w). (en)
Title
  • Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider
  • Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider (en)
skos:prefLabel
  • Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider
  • Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider (en)
skos:notation
  • RIV/62157124:16370/09:00002090!RIV10-MSM-16370___
http://linked.open...avai/riv/aktivita
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  • 306994
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  • RIV/62157124:16370/09:00002090
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  • Maclura pomifera (Rafin.) Schneider; Osage orange; Moraceae; Anticholinesterase; Isoflavone; LC?DAD?MS (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [F05C2C85A3CA]
http://linked.open...i/riv/nazevZdroje
  • Food and Chemical Toxicology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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  • 47
http://linked.open...iv/tvurceVysledku
  • Mokrý, Petr
  • Šmejkal, Karel
  • Žemlička, Milan
  • Dvorská, Margita
  • Kartal, Murat
  • Orhan, Ilkay
  • Senol, Sezer
http://linked.open...ain/vavai/riv/wos
  • 000269100700004
issn
  • 0278-6915
number of pages
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  • 16370
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