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  • The study examined the antimicrobial activity of 2-hydroxy-3-[4-(2-fluoro, 4-fluoro, and 2-metoxyphenyl)-piperazin-l-yl]-propyl- 4-[(alkoxycarbonyl)amino] benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of the carbamoyl group studied and described. The series of these substances were evaluated in vitro against Mycobacterium kansasii 6 509/96. The correlation of this activity with lipophilicity (log k') was used to describe the structure-antimycobacterial activity relationships (QSARs). The tests have shown that practically all the substances under study possess antituberculotic activity. In vitro antimycobacterial activity increased with increasing lipophilicity. According to the obtained results, the substances can be considered as potential antituberculotics.
  • The study examined the antimicrobial activity of 2-hydroxy-3-[4-(2-fluoro, 4-fluoro, and 2-metoxyphenyl)-piperazin-l-yl]-propyl- 4-[(alkoxycarbonyl)amino] benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of the carbamoyl group studied and described. The series of these substances were evaluated in vitro against Mycobacterium kansasii 6 509/96. The correlation of this activity with lipophilicity (log k') was used to describe the structure-antimycobacterial activity relationships (QSARs). The tests have shown that practically all the substances under study possess antituberculotic activity. In vitro antimycobacterial activity increased with increasing lipophilicity. According to the obtained results, the substances can be considered as potential antituberculotics. (en)
Title
  • Antimycobacterial activity of novel derivatives of arylcarbonyloxyaminopropanols
  • Antimycobacterial activity of novel derivatives of arylcarbonyloxyaminopropanols (en)
skos:prefLabel
  • Antimycobacterial activity of novel derivatives of arylcarbonyloxyaminopropanols
  • Antimycobacterial activity of novel derivatives of arylcarbonyloxyaminopropanols (en)
skos:notation
  • RIV/62157124:16370/09:00002079!RIV10-MSM-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 5-6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 303496
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/09:00002079
http://linked.open...riv/jazykVysledku
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  • Antimycobacterial activity; Antituberculotic activity; Arylcarbonyloxyaminopropanols; Lipophilicity; Phenylcarbamates; Potential antituberculotics (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [D1916A031D47]
http://linked.open...i/riv/nazevZdroje
  • Česká a slovenská farmacie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 58
http://linked.open...iv/tvurceVysledku
  • Andriamainty, Fils
  • Csöllei, Jozef
  • Kaustová, Jarmila
  • Malík, Ivan
  • Mokrý, Petr
  • Sedlárová, Eva
  • Čižmárik, Jozef
  • Kečkéšová, Simona
  • Garaj, Vladimír
issn
  • 1210-7816
number of pages
http://localhost/t...ganizacniJednotka
  • 16370
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