About: Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than that of the standard isoniazid. It was found that the electronic properties of the R substituent, and not the total lipophilicity of the compound, were decisive for the photosynthesis-inhibiting activity of tested compounds. In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than that of the standard isoniazid. It was found that the electronic properties of the R substituent, and not the total lipophilicity of the compound, were decisive for the photosynthesis-inhibiting activity of tested compounds. (en)
Title	Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues (en)
skos:prefLabel	Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues (en)
skos:notation	RIV/62157124:16370/09:00002077!RIV10-MSM-16370___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6215712403)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jampílek, Josef Dohnal, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	320292
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/09:00002077
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	styrylquinazolinone and styrylquinazoline derivatives; lipophilicity; PET inhibition; spinach chloroplasts; in vitro antimycobacterial activity; in vitro antifungal activity; structure-activity relationships (en)
http://linked.open.../riv/klicoveSlovo	structure-activity relationships PET inhibition in vitro antifungal activity in vitro antimycobacterial activity spinach chloroplasts lipophilicity styrylquinazolinone and styrylquinazoline derivatives
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[FDBEBB9F5E9D]
http://linked.open...i/riv/nazevZdroje	Molecules
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Dohnal, Jiří Jampílek, Josef Kráľová, Katarína Peško, Matúš Vejsová, Marcela Coffey, Aidan Polański, Jarosław O'Mahony, Jim Musioł, Robert Carroll, James Finster, Jacek
http://linked.open...ain/vavai/riv/wos	000271265300030
http://linked.open...n/vavai/riv/zamer	Active creation of health, yield and performance of the large animals
issn	1420-3049
number of pages	20 (xsd:int)
http://localhost/t...ganizacniJednotka	16370
is http://linked.open...avai/riv/vysledek of	Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues

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