About: Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu     Goto   Sponge   NotDistinct   Permalink

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  • S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately it seems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the most dangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals.
  • S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately it seems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the most dangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals. (en)
Title
  • Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu
  • Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu (en)
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  • Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu
  • Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu (en)
skos:notation
  • RIV/62157124:16370/08:00002550!RIV10-MSM-16370___
http://linked.open...avai/riv/aktivita
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  • V
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  • Suppl.1
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  • 365258
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  • RIV/62157124:16370/08:00002550
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  • Stereoisomery; Aryloxyaminopropanols (en)
http://linked.open.../riv/klicoveSlovo
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  • CZ - Česká republika
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  • [8E1AC21ED3E3]
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  • Prague Medical Report
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  • 109
http://linked.open...iv/tvurceVysledku
  • Mokrý, Petr
  • Suchý, Pavel
  • Opatřilová, Radka
  • Parák, Tomáš
  • Bartošová, Ladislava
  • Beránková, Klára
  • Brunclík, Vít
  • Frydrych, Marek
  • Kolevská, Jana
  • Součková, Irena
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  • 1214-6994
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  • 16370
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