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  • Práce se věnuje syntéze, ověření struktury a studiu fyzikálně-chemických vlastností derivátů aryloxyaminopropanolu, 2-hydroxy-3-[4-(2-fluorfenyl)-piperazin-1-yl]propyl-4-[(alkoxykarbonyl)amino]benzoátů, jejich solí s kyselinou chlorovodíkovou, s jedním až čtyřmi atomy uhlíku v alkoxyskupině karbamoylové skupiny. Struktura sloučenin byla potvrzena elementární analý­zou, IČ, UV a hmotnostními spektry. V rámci studia byla stanovena teplota tání, rozpustnost, povrchová aktivita, disociační konstanta, a též parametry lipofility, t.j. rozdělovací koeficient P, hodnoty RM z reverzní chromatografie na tenké vrstvě a retenční faktor k pomocí vysokoúčin­ná kvapalinové chromatografie. (cs)
  • 1.The paper deals with the synthesis, structure confirmation, and study of physicochemical properties of some aryloxyaminopropanol derivatives, compounds of 2-hydroxy-3-[4-(2-fluoropheny1)- piperazine-l-yl]-propyl-4-[(alkoxycarbonyl)amino]benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of the carbamoyl group. Their structure was confirmed by elemental analysis, IR, UV and mass spectra. The melting point, solubility, surface activity, dissociation constant, and some lipophilicity parameters, i.e. partition coefficient P, RM values from reversed phase thin-layer chromatography, and retention factor k obtained from HPLC of the substances under study were determined.
  • 1.The paper deals with the synthesis, structure confirmation, and study of physicochemical properties of some aryloxyaminopropanol derivatives, compounds of 2-hydroxy-3-[4-(2-fluoropheny1)- piperazine-l-yl]-propyl-4-[(alkoxycarbonyl)amino]benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of the carbamoyl group. Their structure was confirmed by elemental analysis, IR, UV and mass spectra. The melting point, solubility, surface activity, dissociation constant, and some lipophilicity parameters, i.e. partition coefficient P, RM values from reversed phase thin-layer chromatography, and retention factor k obtained from HPLC of the substances under study were determined. (en)
Title
  • Synthesis, identification and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers
  • Syntéza, identifikace a fyzikálně-chemické vlastnosti nových potenciálních ultrakrátce působících beta-adrenergních blokátorů (cs)
  • Synthesis, identification and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers (en)
skos:prefLabel
  • Synthesis, identification and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers
  • Syntéza, identifikace a fyzikálně-chemické vlastnosti nových potenciálních ultrakrátce působících beta-adrenergních blokátorů (cs)
  • Synthesis, identification and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers (en)
skos:notation
  • RIV/62157124:16370/08:00002060!RIV09-MSM-16370___
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  • 4
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  • 398762
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  • RIV/62157124:16370/08:00002060
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  • 1.ultrashort-acting beta-blockers; synthesis; physicochemical properties (en)
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  • CZ - Česká republika
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  • [4D26AFEA26C5]
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  • Česká a slovenská farmacie
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  • 57
http://linked.open...iv/tvurceVysledku
  • Csöllei, Jozef
  • Mokrý, Petr
  • Sedlárová, Eva
  • Kečkéšová, Simona
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  • 1210-7816
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  • 16370
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