About: Protective effects of osajin in ischemia-reperfusion.     Goto   Sponge   NotDistinct   Permalink

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Description
  • Cílem studie bylo analyzovat antioxidační efekt osajinu při profylaktickém podávání. Patologickým stavem byla pro experiment unilaterální ischemie-reperfuze ledviny laboratorního potkana. Osajin byl podáván ve třech dávkách jednou denně. Patnáctidenní premedikace byla ukončena 60 min ischemií levé ledviny v celkové anestezii. Reperfuze trvala 10 min. Sledovány byly tyto biochemické parametry: superoxiddismutáza, glutathion peroxidáza, celková antioxidační kapacita a malondialdehyd. Vzorky ledvinné tkáně byly odebrány pro histopatologické vyšetření. Biochemické i histopatologické výsledky potvrdily předpokládaný efekt osajinu. (cs)
  • The aim of this study was to analyze the antioxidative effect of osajin during prophylactic administration. The pathological was the unilateral ischemia-reperfusion of kidney of the laboratory rat. Osajin was administrated orally in doses of 5, 10 and 20 mg/kg once a day to premedicated groups. The premedication lasted 15 days and subsequently the ischemia of the left kidney was incited in general anaesthesia for 60 min. The reperfusion lasted 10 min. Selected biochemical markers were assessed in blood: superoxide dismutase, glutathion peroxidase, total antioxidative capacity and malondialdehyde. The kidney tissue samples were used for histopathological examination. Laboratory and histopathological results confirmed supposed effects of osajine.
  • The aim of this study was to analyze the antioxidative effect of osajin during prophylactic administration. The pathological was the unilateral ischemia-reperfusion of kidney of the laboratory rat. Osajin was administrated orally in doses of 5, 10 and 20 mg/kg once a day to premedicated groups. The premedication lasted 15 days and subsequently the ischemia of the left kidney was incited in general anaesthesia for 60 min. The reperfusion lasted 10 min. Selected biochemical markers were assessed in blood: superoxide dismutase, glutathion peroxidase, total antioxidative capacity and malondialdehyde. The kidney tissue samples were used for histopathological examination. Laboratory and histopathological results confirmed supposed effects of osajine. (en)
Title
  • Protective effects of osajin in ischemia-reperfusion.
  • Protective effects of osajin in ischemia-reperfusion. (en)
  • Protektivní efekt osajinu v ischemii-reperfuzi ledviny laboratorního potkana. (cs)
skos:prefLabel
  • Protective effects of osajin in ischemia-reperfusion.
  • Protective effects of osajin in ischemia-reperfusion. (en)
  • Protektivní efekt osajinu v ischemii-reperfuzi ledviny laboratorního potkana. (cs)
skos:notation
  • RIV/62157124:16370/06:00000701!RIV07-MZ0-16370___
http://linked.open.../vavai/riv/strany
  • 552-555
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
  • 6
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  • 495679
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  • RIV/62157124:16370/06:00000701
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  • kidney (en)
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  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [D401036BCD8D]
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  • Pharmazie
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http://linked.open...ichTvurcuVysledku
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 61
http://linked.open...iv/tvurceVysledku
  • Bartošík, Tomáš
  • Juřica, Jan
  • Suchý, Václav
  • Nečas, Jiří
  • Bartošíková, Lenka
  • Frydrych, Marek
  • Florian, Tomáš
  • Janoštíková, Eva
  • Klusáková, Jana
issn
  • 0031-7144
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  • 16370
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