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| Description
| - Three newly synthesized potential ultrashort-acting beta adrenergic blockers containing metabolically unstable ester functional groups that are easily cleft by plasma esterases were tested. In the experiment, 30 laboratory rats divided into 4 subgroups were used. Agent 42Bu was administered to Group 1 (n = 8), agent 43Bu to Group 2 (n = 8), agent 44Bu to Group 3 (n = 8) and placebo to Group 4 (n = 6). Under general anesthesia the arteria carotis and vena jugularis were exteriorized. The arteria carotis was connected by a cannula to the machine HSE UNIPER UP 100, a universal perfusion system for isolated organs recording and converting actual values of blood pressure into graphical representation in a computer. Subsequently, 42Bu, 43Bu, 44Bu and placebo were administered into v. jugularis, and systolic blood pressure was recorded within the period of 18 minutes of their administration. All agents were administered at 2.5 mg/kg doses. The systolic blood pressure values after 42Bu, 43Bu, 44Bu administrat
- Three newly synthesized potential ultrashort-acting beta adrenergic blockers containing metabolically unstable ester functional groups that are easily cleft by plasma esterases were tested. In the experiment, 30 laboratory rats divided into 4 subgroups were used. Agent 42Bu was administered to Group 1 (n = 8), agent 43Bu to Group 2 (n = 8), agent 44Bu to Group 3 (n = 8) and placebo to Group 4 (n = 6). Under general anesthesia the arteria carotis and vena jugularis were exteriorized. The arteria carotis was connected by a cannula to the machine HSE UNIPER UP 100, a universal perfusion system for isolated organs recording and converting actual values of blood pressure into graphical representation in a computer. Subsequently, 42Bu, 43Bu, 44Bu and placebo were administered into v. jugularis, and systolic blood pressure was recorded within the period of 18 minutes of their administration. All agents were administered at 2.5 mg/kg doses. The systolic blood pressure values after 42Bu, 43Bu, 44Bu administrat (en)
- V této experimantální práci byly testovány tři nově syntetizované ultrakrátce působící beta adrenergní blokátory obsahující ve své struktuře esterovou funkční skupinu, která je snadno štěpitelná plazmatickými esterázami. Testovaná skupina zvířat obsahovala 30 laboratorních potkanů rozdělených do tří podskupin. Látka 42Bu byla podávána první skupině (8 potkanů), látka 43Bu druhé skupině (8 potkanů), látka 44Bu třetí skupině (8 potkanů) a čtvrté skupině bylo podáváno placebo (6 potkanů). V celkové anestézii byly vypreparovány arteria carotis a vena jugularis. Arteria carotis byla připojena na přístroj HSE UNIPER UP-100, což je univerzální perfúzní systém pro izolované orgány snímající a převádějící aktuální hodnoty krevního tlaku na grafický záznam do PC. Následně byly do vena jugularis jednorázově injikovány roztoky látek 42Bu, 43Bu, 44Bu a placeba a hodnoty krevního tlaku byly snímány po dobu 18 minut od aplikace. Látky 42Bu, 43Bu a 44Bu byly aplikovány v dávce 2,5 mg/kg. Zkoumané látky byly porovnány (cs)
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| Title
| - Influence of New Ultrashort-Acting Beta-Adrenergic Blockers on Systolic Blood Pressure in Rats
- Influence of New Ultrashort-Acting Beta-Adrenergic Blockers on Systolic Blood Pressure in Rats (en)
- Vliv nový ultrakrátce působících beta adrenergních blokátorů na systolický krevní tlak laboratorního potkana (cs)
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| skos:prefLabel
| - Influence of New Ultrashort-Acting Beta-Adrenergic Blockers on Systolic Blood Pressure in Rats
- Influence of New Ultrashort-Acting Beta-Adrenergic Blockers on Systolic Blood Pressure in Rats (en)
- Vliv nový ultrakrátce působících beta adrenergních blokátorů na systolický krevní tlak laboratorního potkana (cs)
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| skos:notation
| - RIV/62157124:16370/04:00000014!RIV06-MSM-16370___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16370/04:00000014
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - pharmacology; plasma esterases; ester functional group; universal perfusion system; hypotensive effect (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Mokrý, Petr
- Nečas, Jiří
- Bartošová, Ladislava
- Bartošíková, Lenka
- Brunclík, Vít
- Frydrych, Marek
- Krčmář, Josef
- Florian, Tomáš
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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