About: Evaluation of norfloxacin toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress

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About: Evaluation of norfloxacin toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target. Toxicity test was performed on zebrafish according to the OECD Guideline No. 215 (subchronic toxicity test). In the test, there was found a significant (p{0.01) increase in the activity of glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT). Norfloxacin did not affect lipid peroxidation (TBARS) and catalytic activity of glutathione reductase (GR). From the results we can conclude that norfloxacin has a negative impact on specific biochemical processes connected with the production of reactive oxygen species in fish tested. The aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target. Toxicity test was performed on zebrafish according to the OECD Guideline No. 215 (subchronic toxicity test). In the test, there was found a significant (p{0.01) increase in the activity of glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT). Norfloxacin did not affect lipid peroxidation (TBARS) and catalytic activity of glutathione reductase (GR). From the results we can conclude that norfloxacin has a negative impact on specific biochemical processes connected with the production of reactive oxygen species in fish tested. (en)
Title	Evaluation of norfloxacin toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress Evaluation of norfloxacin toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress (en)
skos:prefLabel	Evaluation of norfloxacin toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress Evaluation of norfloxacin toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress (en)
skos:notation	RIV/62157124:16270/14:43872896!RIV15-MSM-16270___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Bartošková, Marta Blahová, Jana Stancová, Vlasta Dobšíková, Radka Pána, Ondřej Plhalová, Lucie Maršálek, Petr Živná, Dana
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Fakulta veterinární hygieny a ekologie
http://linked.open...dnocenehoVysledku	15403
http://linked.open...ai/riv/idVysledku	RIV/62157124:16270/14:43872896
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lipid peroxidation; oxidative stress enzymes; toxicity test; fish; fluoroquinolone (en)
http://linked.open.../riv/klicoveSlovo	fluoroquinolone fish oxidative stress enzymes toxicity test lipid peroxidation
http://linked.open...ontrolniKodProRIV	[7714BBB4E120]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	XVI. Konference mladých vědeckých pracovníků s mezinárodní účastí Sborník příspěvků
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Blahová, Jana Maršálek, Petr Plhalová, Lucie Dobšíková, Radka Stancová, Vlasta Živná, Dana Bartošková, Marta Pána, Ondřej
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2014-05-28 (xsd:date)
number of pages	3 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Veterinární a farmaceutická univerzita Brno
https://schema.org/isbn	978-80-7305-670-4
http://localhost/t...ganizacniJednotka	16270

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