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  • Usage of crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta 89Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyklin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates.
  • Usage of crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta 89Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyklin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates. (en)
Title
  • Use of Crustacean Artemia franciscana for Alternative Biotests
  • Use of Crustacean Artemia franciscana for Alternative Biotests (en)
skos:prefLabel
  • Use of Crustacean Artemia franciscana for Alternative Biotests
  • Use of Crustacean Artemia franciscana for Alternative Biotests (en)
skos:notation
  • RIV/62157124:16270/10:00002769!RIV11-MSM-16270___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6215712402)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 294659
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16270/10:00002769
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Artemia salina; Synergy effects; irradiation; pharmacotoxicology (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [A45CA73D77A5]
http://linked.open...i/riv/nazevZdroje
  • Acta veterinaria Brno
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 79
http://linked.open...iv/tvurceVysledku
  • Dvořák, Petr
  • Havelková, Alena
  • Ždárský, Michal
  • Beňová, Katarína
  • Sklenář, Zbyněk
http://linked.open...ain/vavai/riv/wos
  • 000282195800008
http://linked.open...n/vavai/riv/zamer
issn
  • 0001-7213
number of pages
http://localhost/t...ganizacniJednotka
  • 16270
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