| Attributes | Values |
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| rdf:type
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| Description
| - The aim of this study was to verify these data in growing piglets and newly investigate the role of resveratrol during simultaneous ?-glucan supplementation. 6-week-old Large White breed piglets were divided into one control group (C) and two experimental groups: R (resveratrol) and RG (resveratrol + ?-glucan). Resveratrol isolated from Polygonum cuspidatum root and beta-glucan gained from Saccharomyces cerevisiae were soluted in 15% alcohol and administered to the piglets by gastric probe in a daily dose 3 mg/kg0.75 of body weight. Control piglets obtained only alcohol solution. Blood samples were collected by puncture of v. jugularis and tested for number of platelets, platelet aggregation and speed of platelet aggregation after stimulation by ADP and cationic propylgallate. In comparison to control piglets number of platelets dropped markedly in both experimental groups. After one week of supplementation (R: P{0.05; RG: P{0.01) and after 2 weeks (both R and RG: P{0.01). Aggregation induced by ADP was significantly reduced after 2 weeks in both experimental groups (R: P{0.01; RG: P{0.05) while aggregation induced by cationic propylgallate was significantly reduced only in RG after 2 weeks (P{0.05). Speed of aggregation (slope) induced by ADP significantly decreased after 2 weeks (both R and RG: P{0.01). Speed of aggregation (slope) induced by cationic propylgallate significantly decreased in both experimental groups (R: P{0.05; RG: P{0.01). Results suggest that neither suppressive effect of resveratrol on platelet numbers nor its %22aspirin-like%22 effect is inhibited by simultaneous administration of beta-glucan. On the contrary we demonstrated synergistic effect of both agents in experimental piglets.
- The aim of this study was to verify these data in growing piglets and newly investigate the role of resveratrol during simultaneous ?-glucan supplementation. 6-week-old Large White breed piglets were divided into one control group (C) and two experimental groups: R (resveratrol) and RG (resveratrol + ?-glucan). Resveratrol isolated from Polygonum cuspidatum root and beta-glucan gained from Saccharomyces cerevisiae were soluted in 15% alcohol and administered to the piglets by gastric probe in a daily dose 3 mg/kg0.75 of body weight. Control piglets obtained only alcohol solution. Blood samples were collected by puncture of v. jugularis and tested for number of platelets, platelet aggregation and speed of platelet aggregation after stimulation by ADP and cationic propylgallate. In comparison to control piglets number of platelets dropped markedly in both experimental groups. After one week of supplementation (R: P{0.05; RG: P{0.01) and after 2 weeks (both R and RG: P{0.01). Aggregation induced by ADP was significantly reduced after 2 weeks in both experimental groups (R: P{0.01; RG: P{0.05) while aggregation induced by cationic propylgallate was significantly reduced only in RG after 2 weeks (P{0.05). Speed of aggregation (slope) induced by ADP significantly decreased after 2 weeks (both R and RG: P{0.01). Speed of aggregation (slope) induced by cationic propylgallate significantly decreased in both experimental groups (R: P{0.05; RG: P{0.01). Results suggest that neither suppressive effect of resveratrol on platelet numbers nor its %22aspirin-like%22 effect is inhibited by simultaneous administration of beta-glucan. On the contrary we demonstrated synergistic effect of both agents in experimental piglets. (en)
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| Title
| - Synergistic effects of beta-glucan and resveratrol on platelet aggregation
- Synergistic effects of beta-glucan and resveratrol on platelet aggregation (en)
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| skos:prefLabel
| - Synergistic effects of beta-glucan and resveratrol on platelet aggregation
- Synergistic effects of beta-glucan and resveratrol on platelet aggregation (en)
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| skos:notation
| - RIV/62157124:16170/14:43873320!RIV15-MSM-16170___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16170/14:43873320
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - pig; platelet aggregation; resveratrol; beta-glucan (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Chlastáková, Ivana
- Doubek, Jaroslav
- Kotrbáček, Václav
- Tomenendálová, Jaroslava
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| http://localhost/t...ganizacniJednotka
| |
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